Restricted to biomedical engineering majors. Working principles of biomolecules such as proteins and nucleic acids. Physical and chemical basis for biomolecular structure, energetics, and function. Three hours of lecture a week for one semester. Offered on the letter-grade basis only. Prerequisite: The following coursework with a grade of at least C-: Biochemistry 369; Biology 311C or 315H; Mathematics 427J; Physics 303L; and Physics 103N or 105N.