Integration of nursing knowledge derived from didactic and clinical courses with application in the care of clients across the life span and in a variety of settings. One lecture hour and twelve laboratory hours a week for one semester. Nursing 484S and 187S may not both be counted. Nursing 484S and 290S may not both be counted. Prerequisite: Graduate standing, admission to the alternate entry MSN program, and Nursing 484H, 384J, and 484R.