UTexas

Biomedical Engineering (BME)

BME 303  Introduction to Computing  3 Hours  

5 Lecture Hours  0 Lab Hours  
Introduction to computing and programming, focusing on high-level programming languages. Emphasis on programming skills using C++ and Python as well as data acquisition using open-source computer hardware. Emphasis is on biomedical engineering applications for computing. Three lecture hours and two recitation hours a week for one semester.
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Lower Division  

BME 303L  Introduction to Biomedical Engineering Design  3 Hours  

3 Lecture Hours  3 Lab Hours  
Biomedical engineering design concepts with hands-on learning applications. Biomedical Engineering 102L and 203L, 303L may not both be counted. Three lecture hours and three laboratory hours a week for one semester.
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Lower Division  

BME 306  Fundamentals of Computing  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to computing including bits and operations on bits, number formats, arithmetic and logic operations, digital logic. Explore the Von Neumann model of processing including memory, arithmetic logic unit, registers, and instruction decoding and execution. Examine structured programming and debugging, machine and assembly language programming, the structure of an assembler, physical input/output through device registers, subroutine call/return; trap instruction, stacks and applications of stacks. Only one of the following may be counted: Biomedical Engineering 306, Electrical and Computer Engineering 306, 306H, Electrical Engineering 306, 306H. Three lecture hours a week for one semester. Additional lab hours to be arranged.
Pre/Corequisites: Credit with a grade of at least C- or registration for Mathematics 408C or 408K.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Lower Division  

BME 311  Network Analysis in Biomedical Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Basic concepts in circuit analysis and design of systems for biomedical engineering; Ohm's law, Kirchhoff's laws, and nodal and loop analysis; Theyenin's and Norton's theorem; operational amplifiers; high-order circuit and basic AC circuit analysis using Fourier and Laplace transforms. Only one of the following may be counted: Biomedical Engineering 311, Electrical and Computer Engineering 411, 411H, Electrical Engineering 411. Three lecture hours a week for one semester.
Pre/Corequisites: Physics 303K with a grade of at least C-; and credit with a grade of at least C- or registration for: Mathematics 427J and Physics 303L.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Lower Division  

BME 313L  Introduction to Numerical Methods in Biomedical Engineering  3 Hours  

3 Lecture Hours  3 Lab Hours  
Introduces principles and techniques of numerical analysis of biomedical engineering problems. Examines numerical methods of integration, differentiation, interpolation, curve fitting, data analysis, sampling and estimation, error analysis, analysis of ordinary differential equations, numerical modeling of biomedical engineering systems, symbolic computation, and scientific visualization. Only one of the following may be counted: Aerospace Engineering 211K, 311, Biomedical Engineering 313L, Computational Engineering 211K, 311K. Three lecture hours and three laboratory hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 303 or Computational Engineering 301, Biomedical Engineering 303L, and Mathematics 427J.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Lower Division  

BME 214L  Computational Fundamentals of Biomedical Engineering Design  2 Hours  

2 Lecture Hours  3 Lab Hours  
Overview of computational methods used to model biomedical systems, analyze data, and assist in the engineering design process. Subjects and hands-on learning applications include 3D modeling tools and computer aided manufacturing, flow simulation, instrumentation, biomedical imaging modalities, and biomedical informatics. Biomedical Engineering 314 and 214L may not both be counted. Two lecture hours and three laboratory hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 303 or Computational Engineering 301, Biomedical Engineering 303L, Physics 303K, and Physics 103M or 105M; and credit with a grade of at least C- or registration for: Biomedical Engineering 311 or Electrical and Computer Engineering 411 (or Electrical Engineering 411), Mathematics 427J, Physics 303L, and Physics 103N or 105N.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Lower Division  

BME 117T, 217T, 317T  Introductory Topics in Biomedical Engineering  1-3 Hours  

1,2,3 Lecture Hours  0 Lab Hours  
For each semester hour of credit earned, the equivalent of one lecture hour a week for one semester.
Pre/Corequisites: Prerequisites vary with the topic.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Lower Division  

BME 320  International Perspectives on Biomedical Engineering Design  3 Hours  

3 Lecture Hours  0 Lab Hours  
Activities to consider sociotechnical factors in designing clinically translatable solutions with a focus on international perspectives. Biomedical Engineering 320 and 377T (Topic: International Perspectives on Biomedical Engineering Design) may not both be counted. Three lecture hours a week for one semester.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 321D  Introduction to Medical Image Processing  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to theories, methods, and applications related to medical image processing through project-based learning. Discuss the principles and approaches for image segmentation, image registration, and deep learning classification, in addition to the global reach of clinical applications based on these methods, such as radiology and radiation oncology. Biomedical Engineering 321D and 377T (Topic: Medical Image Processing) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: One of the following with a grade of at least C-: Biomedical Engineering 303, Electrical and Computer Engineering 306, 306H.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 322  Health Equity in Engineering Design  3 Hours  

3 Lecture Hours  0 Lab Hours  
Discuss healthcare disparities and causal mechanisms that lead to differential patient outcomes of medical devices and therapeutics. Assess how engineers can improve the design process of healthcare technologies to remove bias and improve equity. Explore current research in the field from health disparity specialists. Biomedical Engineering 322 and 377T (Topic: Health Equity in Engr Design) may not both be counted. Three lecture hours a week for one semester.
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 129S, 229S, 329S, 429S, 529S, 629S, 729S, 829S, 929S  Topics in Biomedical Engineering  1-9 Hours  

1,2,3,4,5,6,7,8,9 Lecture Hours  0 Lab Hours  
This course is used to record credit the student earns while enrolled at another institution in a program administered by the University's Study Abroad Office. Credit is recorded as assigned by the study abroad adviser in the Department of Biomedical Engineering. University credit is awarded for work in an exchange program; it may be counted as coursework taken in residence. Transfer credit is awarded for work in an affiliated studies program.
Grading: Letter Grade  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Upper Division  

BME 335  Engineering Probability and Statistics  3 Hours  

4 Lecture Hours  0 Lab Hours  
Fundamentals of probability, random processes, and statistics with emphasis on biomedical engineering applications. Includes hypothesis testing, regression, and sample size calculations. The equivalent of four lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 303 or Computational Engineering 301, and Mathematics 408D or 408M with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 336  Cancer Bioengineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Comprehensive overview of the biology and pathology of cancer. Emphasis on the fundamental nature of cancer, the roles of genetics and the environment, and the contributions of heterotypic tissues in the tumor microenvironment. Exploration of current challenges in the field and ways that various engineering tools are transforming the future of cancer research. Biomedical Engineering 336 and 377T (Topic: Cancer Bioengineering) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Upper-division standing, Biochemistry 369 and Biology 311C or 315H with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 337  Nanomedicine  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore the fundamental properties, synthesis, and characterization of nanomaterials, including their applications in nanomedicine. Discuss micro- and nano-particles for drug delivery and imaging, microfluidics for in vitro diagnostics and biological systems modeling, and nanomaterials and platforms for biological applications. Examine biomedical applications such as cancer, cardiovascular disease, and infectious diseases. Biomedical Engineering 337 and 377T (Topic: Nanomedicine) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 349 and 352 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 338  Thin Film Mechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine mechanical testing, design, and failure analysis of thin film structures and devices, with an emphasis on mechanics-related subjects including stress, fracture, delamination, and instability. Explore important technological applications of film materials, including integrated circuits, micro- and nano-electromechanical systems, flexible and stretchable electronics, bioelectronics, and surface coatings. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 349 and 352 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 339  Biochemical Engineering  3 Hours  

4 Lecture Hours  0 Lab Hours  
Principles of fermentation and cell culture technologies; introduction to recombinant DNA technology and protein expression; the development of therapeutics, vaccines, and diagnostics using genetic engineering. Only one of the following may be counted: Biology 335, Biomedical Engineering 339, 344C, 377T (Topic: Introduction to Therapeutics), Chemical Engineering 339, 344, 379 (Topic: Introduction to Therapeutics), Molecular Biosciences 337 (Topic: Introduction to Therapeutics). The equivalent of four lecture hours a week for one semester.
Pre/Corequisites: Upper-division standing, Biochemistry 369 and Biology 311C or 315H with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 340  Soft Tissue Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore soft tissues and soft tissue mechanics. Examine fundamentals of continuum mechanics (kinematics, stress, balance of linear momentum, hyperelasticity), experimental and nonlinear finite element analysis of soft tissue mechanics, and relevant imaging modalities and facilities available on campus. Biomedical Engineering 340 and 377T (Topic: Soft Tissue Biomechanics) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 and 353 with a grade of at least C- in each; and consent of instructor.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 342  Biomechanics of Human Movement  3 Hours  

3 Lecture Hours  0 Lab Hours  
Modeling and simulation of human movement; neuromuscular control; computer applications; introduction to experimental techniques. Biomedical Engineering 342 and Mechanical Engineering 354M may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 344 or Engineering Mechanics 319 with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 343  Biomedical Engineering Signal and Systems Analysis  3 Hours  

3 Lecture Hours  0 Lab Hours  
Signals and systems representation; sampling and quantization; time and frequency domains; Laplace and z-transforms, transfer functions, and frequency response; two-port networks; Bode plots; convolution; stability; Fourier series; Fourier transform; AM/FM modulation; filter design; and applications in biomedical engineering. Only one of the following may be counted: Biomedical Engineering 343, Electrical and Computer Engineering 313, 313H, Electrical Engineering 313. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 311 or Electrical and Computer Engineering 411 (or Electrical Engineering 411), Biomedical Engineering 313L or Computational Engineering 311K, and Mathematics 427J.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 344  Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine the principles of engineering mechanics and their applications to basic problems in biomechanics and biomedical engineering. Explore internal forces and deformations in solids, including stress, strain, tension, compression, torsion, bending, internal pressure, and failure analysis under combined mechanical loading. Biomedical Engineering 344 and 377T (Topic: Biomechanics) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 303L, Mathematics 427J, and Physics 303K.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 344C  Introduction to Therapeutics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to the biological and engineering underpinnings of therapeutics discovery, development and manufacturing. Focus on the quantitative and engineering principles relevant to growing cells and producing molecules for commercial purposes, including basic growth kinetics and stoichiometry, simple bioreactor design and oxygen transfer. Only one of the following may be counted: Biology 335, Biomedical Engineering 339, 344C, 377T (Topic: Introduction to Therapeutics), Chemical Engineering 339, 344, 379 (Topic: Introduction to Therapeutics), Molecular Biosciences 337 (Topic: Introduction to Therapeutics). Three lecture hours a week for one semester.
Pre/Corequisites: Upper-division standing, Biochemistry 369, and Biology 311C or 315H with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 345  Graphics and Visualization Laboratory  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to techniques for graphical display of biological data. Subjects include transformations, geometric modeling, and two- and three-dimensional display algorithms. Includes computational projects with biomedical applications. Three lecture hours a week for one semester.
Pre/Corequisites: Electrical and Computer Engineering 422C (or Electrical Engineering 422C) and Mathematics 340L or 341 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 245L  Experimental Principles of Biomedical Engineering Design  2 Hours  

2 Lecture Hours  2 Lab Hours  
Exploration of biomedical engineering design principles through open-ended, hands-on research applications involving mechanical testing, cell culture, and biomaterials. Analysis and interpretation of experimental data, including written reporting of outcomes in scientific journal format. Biomedical Engineering 221 and 245L may not both be counted. Two lecture hours and two laboratory hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biology 206L, Biomedical Engineering 214L, Biomedical Engineering 335 or Mechanical Engineering 335, Biomedical Engineering 344 or Engineering Mechanics 319, and one of the following: Aerospace Engineering 333T, Biomedical Engineering 333T, Chemical Engineering 333T, Civil Engineering 333T, Communication 333T, Electrical and Computer Engineering 333T (or Electrical Engineering 333T), Engineering Studies 333T, Mechanical Engineering 333T, or Petroleum and Geosystems Engineering 333T.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 346  Computational Biomolecular Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to computational structural biology and molecular modeling, including the fundamentals of biomolecular structure and molecular thermodynamics. The principles and applications of biomolecular modeling used to explore the critical relationship between structure, function, and thermodynamic driving forces in molecular biology. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biochemistry 369, Biology 311C or 315H, Biomedical Engineering 313L or Computational Engineering 311K, and one of the following: Biomedical Engineering 355, Chemistry 353 or 353M.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 347  Fundamentals of Biomedical Optics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to the field of biophotonics. Subjects include light scattering theory, tissue optical properties, analytical and numerical techniques for determining light propagation in tissue, light-tissue interactions, and bioheat transfer including solution methods. Biomedical Engineering 347 and 377T (Topic: Fundamentals of Biomedical Engineering Optical Imaging) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 353 or Mechanical Engineering 339 with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 348  Modeling of Biomedical Engineering Systems  3 Hours  

3 Lecture Hours  2 Lab Hours  
Lumped and distributed models of physiological system function from molecular through organismal levels. Linear system steady-state and transient behaviors. Interactions among multiple energy domains, including electrical, chemical, diffusional, mechanical, fluid, and thermal. Introduction to feedback control. Three lecture hours and two laboratory hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 214L, and Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313) with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 348P  Introduction to Computational and Systems Biology  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to big data technology platforms, data science analytical algorithms and artificial intelligence in computational biology and medicine and network science. Examine DNA sequence alignment and search, high-throughput big data platforms and analysis, network science, multi-omics profiling, statistics, motif finding, molecular structure prediction, genome-wide association studies, artificial intelligence, and personalized precision medicine. Explore computational algorithms including hidden Markov model, clustering, classification methods, and others. Only one of the following may be counted: Biomedical Engineering 348P, 377T (Topic: Intro to Comp/Systems Bio), Chemistry 368 (Topic: Intro to Comp/Systems Bio), Computer Science 378 (Topic: Intro to Comp/Systems Bio). Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C- in each: Biochemistry 369, Biology 311C or 315H, Biomedical Engineering 335 or Mechanical Engineering 335, and Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313).  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 349  Biomedical Instrumentation  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to biomedical instrumentation, design, and applications. Emphasis on the complete instrumentation development cycle, design for bio-compatibility, safety and efficacy, and design considerations specific to various medical specialties. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313) with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 350  Computational Methods for Biomedical Engineers  3 Hours  

3 Lecture Hours  0 Lab Hours  
Study of and hands-on experiences with computational methods commonly employed in biomedical engineering research. Biomedical Engineering 350 and 377T (Topic: Computational Methods for Biomedical Engineers) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 313L or Computational Engineering 311K, Biomedical Engineering 214L, and Biomedical Engineering 335 or Mechanical Engineering 335.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 352  Engineering Biomaterials  3 Hours  

3 Lecture Hours  0 Lab Hours  
Overview of properties of metallic, ceramic, polymeric, and composite biomaterials used in biomedical applications. Material synthesis and processing. Analysis of mechanical and chemical properties, including stress-strain. Material interactions with the body and blood. Soft and hard biomaterials applications. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biochemistry 369, and Biomedical Engineering 344 or Engineering Mechanics 319.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 353  Transport Phenomena in Living Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to the principles of heat, mass and momentum transfer and their application to solve problems in living systems. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 311 or Electrical and Computer Engineering 411 (or Electrical Engineering 411); Biomedical Engineering 214L; Mathematics 427J; Physics 303L; and Physics 103N or 105N.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 354  Molecular Sensors and Nanodevices for Biomedical Engineering Applications  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to major types of molecular sensor systems, device miniaturization, and detection mechanisms, including molecular capture mechanisms; electrical, optical, and mechanical transducers; micro-array analysis of biomolecules; semiconductor and metal nanosensors; microfluidic systems; and microelectromechanical systems (MEMS, BioMEMS) fabrication and applications for biomedical engineering. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 313L or Computational Engineering 311K, Biomedical Engineering 335 or Mechanical Engineering 335, and Biomedical Engineering 344 or Engineering Mechanics 319.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 355  Molecular Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Working principles of biomolecules such as proteins and nucleic acids. Physical and chemical basis for biomolecular structure, energetics, and function. Three hours of lecture a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biochemistry 369; Biology 311C or 315H; Mathematics 427J; Physics 303L; and Physics 103N or 105N.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 356  Polymer and Bioconjugate Chemistry  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to synthetic principles of polymeric biomaterials and bioconjugate chemistry with an emphasis on synthetic strategies to achieve specific properties. Explores characterization methods of polymers and bioconjugates as a function of chemical composition, as well as tissue engineering and drug delivery applications as case studies of the biomaterial design process. Biomedical Engineering 356 and 377T (Topic: Polymer/Bioconjugate Chem) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 or Chemical Engineering 350 with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 357  Biomedical Imaging Modalities  3 Hours  

3 Lecture Hours  2 Lab Hours  
Introduction to major biomedical imaging modalities, including X-ray radiography, computed tomography (CT), nuclear medicine (SPECT and PET), magnetic resonance imaging (MRI), and ultrasound. Emphasis on principles, approaches, and applications of each imaging modality. Basic physics and imaging equations of the imaging system; hardware and software; sources of noise and primary artifacts; safety and patient risk. Three lecture hours and two laboratory hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 349 and 261L with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 358  Medical Decision Making  3 Hours  

3 Lecture Hours  0 Lab Hours  
Understanding of the nature of expertise and related subjects of cognitive psychology and human-made interaction to be able to design more effective systems for supporting medical decision making. Biomedical Engineering 358 and 377T (Topic: Medical Decision Making) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 313L or Computational Engineering 311K, Biomedical Engineering 214L, and Biomedical Engineering 335 or Mechanical Engineering 335.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 358M  Imaging Clinical Immersion  3 Hours  

3 Lecture Hours  0 Lab Hours  
Identify current unmet clinical needs via close interaction with healthcare professionals and patients. Explore biomedical imaging across the healthcare enterprise. Biomedical Engineering 358M and 377T (Topic: Imaging Clinical Immersion) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Consent of instructor.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 359  Cellular and Molecular Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to the concepts needed to understand and work in the emerging field of cellular and molecular biomechanics. Examination of dynamic interplay between chemical, thermal, and physical forces in determining the mechanics of cells/tissues and their molecular components. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 344 or Engineering Mechanics 319, and Biomedical Engineering 353 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 261L  Development and Analysis in Biomedical Engineering Design  2 Hours  

2 Lecture Hours  3 Lab Hours  
The design and development of a working biomedical engineering device prototype. Focus on the full engineering design process, including reviews and documentation, and general project management strategies. Also considers the impact of markets, budgets, and the FDA on device requirements and design. Biomedical Engineering 251 and 261L may not both be counted. Two lecture hours and three laboratory hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313), and Biomedical Engineering 245L.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 362  Introduction to Nonlinear Dynamics in Biological Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to various concepts from nonlinear mathematics and their application to biological systems, ranging from sub-cellular to whole ecosystems levels of investigation. Biomedical Engineering 362 and 377T (Topic: Introduction to Nonlinear Dynamics in Biological Systems) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 313L or Computational Engineering 311K, and Biomedical Engineering 344 or Engineering Mechanics 319 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 362C  Advanced Engineering Biomaterials  3 Hours  

3 Lecture Hours  0 Lab Hours  
Analyze biomaterials as components of biomedical implants and delivery vehicles. Discuss basic principles of biocompatibility and implant performance as well as material selection and structure-function relationships. Biomedical Engineering 362C and 377T (Topic: Advanced Engr Biomaterials) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 or Chemical Engineering 350 with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 362E  Medical Device Innovation  3 Hours  

3 Lecture Hours  0 Lab Hours  
Money, markets, and entrepreneurship with particular focus on medical and health markets. Biomedical Engineering 362E and 277T (Topic: Medical Device Innovation: From Lab to Marketplace) may not both be counted. Two lecture hours a week for one semester. Additional hours to be arranged.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 363  Bioelectronics and Biointerfaces  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine critical concepts and strategies in materials development, electronics fabrication and genetic innovations that interface with biological systems. Explore neural interfacing technology, flexible electronics, wearable technology, bio-nanotechnology, and genetic engineering. Focus on the recently developed technology for recording and manipulating neural systems. Biomedical Engineering 363 and 377T (Topic: Bioelectronics/Biointerfaces) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 349 and 352 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 363E  Medical Device Design and Manufacturing  3 Hours  

3 Lecture Hours  0 Lab Hours  
Application of engineering principles in the conception, design and prototyping of medical devices. Development of team projects with emphasis on clinical and market needs analysis, creative and useful concept generation, engineering requirements and specifications, and written and oral reporting of intermediate and final prototype outcomes. Only one of the following may be counted: Biomedical Engineering 363E, 377T (Topic: Medical Device Design and Manufacturing), Mechanical Engineering 371D, 379M (Topic: Medical Device Design and Manu). Three lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 349, 353, and 261L.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 364  Biological Responses to Medical Devices  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore common biological responses elicited by biomaterials and the impact of these responses on material performance. Emphasis on key challenges in the development and assessment of biomaterials used in medical devices. Includes material surface properties, modification, and characterization; protein/cell interactions with materials; biocompatibility, inflammation and wound healing, cell-mediated biodegradation of materials; thrombosis, infection and calcification of medical devices. Biomedical Engineering 364 and 377T (Topic: Biol Responses to Medical Dev) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 365  Tissue Microenvironments  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to, and hands-on applications for, fabrication/bioprinting of tissues on a chip and characterization of mechanical, thermal, transport, and cellular/tissue responses to varying properties of associated microenvironments. Biomedical Engineering 365 and 377T (Topic: Tiss Microenv Fab/Tran/Mech) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 and 353 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 365R  Quantitative Engineering Physiology I  3 Hours  

4 Lecture Hours  0 Lab Hours  
A quantitative, model-oriented approach to human physiology, including basic cellular physiology, electrophysiology of nerve and muscle, the motor system, the central nervous system, and the cardiovascular system. The equivalent of four lecture hours a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biology 311C or 315H, Biomedical Engineering 214L, Physics 303L, and Physics 103N or 105N; and credit with a grade of at least C- or registration for: Biochemistry 369 and Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313).  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 365S  Quantitative Engineering Physiology II  3 Hours  

3 Lecture Hours  0 Lab Hours  
Biological control systems: sensory, renal, respiratory, and immune systems. Focuses on a quantitative, model-oriented approach to physiological systems. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 365R with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 366  Immune Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to various aspects and applications of immune engineering. Subjects include vaccine design, cancer immunotherapy, genomics, infection, auto-immune diseases and emerging tools and methodologies. Biomedical Engineering 366 and 377T (Topic: Immune Engineering) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 365R and 365S with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 367  Design of Artificial Organs  3 Hours  

3 Lecture Hours  0 Lab Hours  
Analysis of the design process for blood-contacting medical devices with an emphasis on ventricular assist devices. Application of computational fluid dynamics and blood rheology to computer-aided design and testing of devices using specific software programs and 3D printing of functioning prototypes. Biomedical Engineering 367 and 377T (Topic: Design of Artificial Organs) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Credit with a grade of at least C- or registration for Biomedical Engineering 353 and 365R.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 367D  Point-of-Care Molecular Diagnostics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to the principles, tools, and technologies required to develop and implement nucleic acid-based molecular diagnostics. Discuss amplification methods, primer design, sample prep, and detection. Focus on global and rural health, accessibility, and real-world applications. Biomedical Engineering 367D and 377T (Topic: Point-of-Care Mol Diagnostics) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 and 355 with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 368  Introduction to Mathematical and Physical Biology  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to common mathematical and physical techniques used in modeling various aspects of biology at multiple spatial and temporal scales. Analyze critical techniques with words and pictures, and then equations including the computational implementation and simulation of those equations. Biomedical Engineering 368 and 377T (Topic: Intro Mathematical & Phys Bio) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313) with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 369  Biomimetic Design and Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Overview of the core concepts of biomimetic microengineering with particular focus on engineered microphysiological models of human organs, tissues and disease pathophysiology. Biomedical Engineering 369 and 377T (Topic: Biomimetic Dsgn/Engineering) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Upper-division standing, Biochemistry 369 and Biology 311C or 315H with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 369C  Matrices, Organoids, and Microphysiological Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore current technologies and scientific literature seeking to construct human-relevant, in vitro systems representing tissues, organs, and disease physiologies as platforms for development of new therapies. Focus on how concepts in biomaterials, stem cell biology, microfluidics, additive manufacturing, and biosensing are integrated to create such platforms. Biomedical Engineering 369C and 377T (Topic: Matrices/Organs/Microphys Sys) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 and 365S with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 370  Biomedical Engineering Capstone Design I  3 Hours  

2 Lecture Hours  3 Lab Hours  
Structured methodologies for designing systems or to interface with living systems. Creative design, analysis, selection, development, and fabrication of biomedical components and systems. Two lecture hours and three laboratory hours a week for one semester.
Core Curriculum: 010  
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 349, 352, 353, 261L, and 365S.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 371  Biomedical Engineering Capstone Design II  3 Hours  

2 Lecture Hours  4 Lab Hours  
Development of team projects in biomedical engineering with emphasis on prototype development and quantitative analysis, and written and oral reporting of the outcome. Two lecture hours and four laboratory hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 370 with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Letter Grade  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 372  Computational Modeling of the Cardiovascular System  3 Hours  

3 Lecture Hours  0 Lab Hours  
Analyze mathematical models and simulations of the cardiovascular system. Examine biomechanical simulations including the biomechanical function of the heart, heart valves, and the vasculature. Biomedical Engineering 372 and 377T (Topic: Comput Modlg: Cardiovasc Sys) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 349 and 365R with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 372C  Delivery of Therapeutic Agents  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore molecular, biological, chemical, and mathematical fundamentals of the use of macromolecular carriers for the release of small and high molecular weight therapeutic agents in vitro and in vivo. Examine design and advanced techniques of protein, peptide, antibodies, and gene therapy. Discuss targeted delivery, mucoadhesive therapy, and theranostics, as well as advanced biomedical devices for treatment of diseases. Biomedical Engineering 372C and 377T (Topic: Delivery of Therapeutic Agents) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 and 353 with a grade of at least C- in each and consent of instructor.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 372P  Mathematical Physiology  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore mathematical modeling in human physiology. Focus on how physiological problems can be formulated and modeled, and how such models give rise to interesting and challenging functional features. Examine several exemplar physiological systems and discuss the mathematical aspects of growth and remodeling in living systems, an area unique to living systems. Biomedical Engineering 372P and 377T (Topic: Mathematical Physiology) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 349 and 365S with a grade of at least C- in each and consent of instructor.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 373  Tissue, Scaffold, and Cell Biomechanics Applications  3 Hours  

3 Lecture Hours  0 Lab Hours  
Fundamentals of biosolid mechanics via the mechanical behavior of scaffolds and living tissues and cells. Emphasis on biomechanical applications to contemporary problems in biomedical research and medical devices. Biomedical Engineering 373 and 377T (Topic: Cell, Tissue and Scaffold Biomechanics for Contemporary Biomedical Engineering Applications) may not both be counted. Three hours of lecture a week for one semester.
Pre/Corequisites: The following coursework with a grade of at least C-: Biomedical Engineering 313L or Computational Engineering 311K, Biomedical Engineering 335 or Mechanical Engineering 335, Biomedical Engineering 344 or Engineering Mechanics 319, Biomedical Engineering 353, 365R, and 365S.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 374  Optical Design  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore the principles of optical design for imaging and laser delivery systems. Examine the development and testing of designs using optical design software. Biomedical Engineering 374 and 377T (Topic: Optical Design) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313) with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 374D  Biomedical Engineering Microscopy Foundations Laboratory  3 Hours  

1.5 Lecture Hours  3 Lab Hours  
Explore finite and infinite imagery; conjugate planes, back focal plan manipulation, Abbe theory image formation, point spread functions, camera principles, fluorescence, and advanced fluorescence techniques, and build an optical microscope. Only one of the following may be counted: Biomedical Engineering 374D, 377T (Topic: Biomd Eng Mcrscpy Fndtn Lab), 377T (Microscopy Fundamentals). One and a half lecture hours and three laboratory hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 343 or Electrical and Computer Engineering 313 (or Electrical Engineering 313) with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 374K  Biomedical Instrument Design  3 Hours  

3 Lecture Hours  0 Lab Hours  
Application of electrical engineering principles in the design of electronic instrumentation at the circuit-board level for the measurement of pressure, temperature, flow, and impedance. Also includes the study of light intensity, bioelectric potentials, and stimulation devices such as pacemakers and defibrillators. Focus on design considerations specific to electro-medical environments, safety and efficacy, and public policy issues. Three lecture hours a week for one semester.
Pre/Corequisites: Electrical and Computer Engineering 438 (or Electrical Engineering 438) with a grade of at least C-.  
Restrictions: Restricted to biomedical engineering and mechanical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 374L  Applications of Biomedical Instrumentation Lab  3 Hours  

3 Lecture Hours  6 Lab Hours  
An in-depth examination of selected subjects in biomedical engineering, including optical and thermal properties of laser interaction with tissue; measurement of perfusion in the microvascular system; diagnostic imaging; interaction of living systems with electromagnetic fields; robotic surgical tools; ophthalmic instrumentation; and noninvasive cardiovascular measurements. Students have the opportunity to design analog and digital measurements and acquire and process meaningful biomedical signals. Three lecture hours and six laboratory hours a week for one semester.
Pre/Corequisites: One of the following with a grade of at least C-: Biomedical Engineering 349, 374K, Electrical and Computer Engineering 438 (or Electrical Engineering 438), or Electrical and Computer Engineering 374K (or Electrical Engineering 374K).  
Restrictions: Restricted to biomedical engineering and mechanical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 375  Stem Cells in Cell and Tissue Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Analysis of recent cell and tissue engineering applications of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC). Focus on case studies of each organ in the human body and how it can be engineered using stem cells. Biomedical Engineering 375 and 377T (Topic: Stem Cells in Cell and Tissue Engineering) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 and 365S with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 376  Cell Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to principles that govern the structure, organization, and processes at cellular and subcellular levels. Special focus on engineering and quantitative aspects of cellular machinery. Employs engineering approaches to study receptors, macromolecular complexes, and cellular signaling; clinical and pharmaceutical approaches to perturb cellular structure and function for disease prevention and drug design. State-of-the-art experimental and computational techniques to study cellular engineering. Three lecture hours a week for one semester.
Pre/Corequisites: Upper-division standing, Biochemistry 369 and Biology 311C or 315H with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 177, 277, 377  Undergraduate Research Project  1-3 Hours  

0 Lecture Hours  3,6,9 Lab Hours  
Initiate opportunity individually and select project in conjunction with a faculty member on the Department of Biomedical Engineering's Graduate Studies Committee (GSC) or in another approved University department. A final written report or the equivalent is required. Recommended for students considering graduate study or medical school. Three, six, or nine laboratory hours a week for one semester.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 377M  Medical Internship  3 Hours  

3 Lecture Hours  0 Lab Hours  
Initiate opportunity individually, which may include participation in a variety of medical and clinical activities which apply engineering principles to solve problems in healthcare. A substantial final report or the equivalent is required. Designed for students considering medical school. The equivalent of three lecture hours a week for one semester.
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 377R  Off-Campus Research  3 Hours  

3 Lecture Hours  0 Lab Hours  
Initiate opportunity individually and select project in conjunction with a faculty member at an approved institution. A final written report or the equivalent is required. The equivalent of three lecture hours a week for one semester.
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 377S  Industrial Internship  3 Hours  

3 Lecture Hours  0 Lab Hours  
Practical work experience in industry or a government agency under the supervision of an engineer, scientist or business professional. A substantial final report or the equivalent is required. The equivalent of three lecture hours a week for one semester.
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 177T, 277T, 377T  Topics in Biomedical Engineering  1-3 Hours  

1,2,3 Lecture Hours  0 Lab Hours  
For each semester hour of credit earned, the equivalent of one lecture hour a week for one semester.
Pre/Corequisites: Prerequisites vary with the topic.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Upper Division  

BME 678  Undergraduate Thesis in Biomedical Engineering  6 Hours  

0 Lecture Hours  0 Lab Hours  
Research performed during two consecutive semesters under the supervision of a biomedical engineering faculty member or other approved faculty member; topics are selected jointly by the student and faculty member. The student provides a progress report at the end of the first semester and writes a thesis and gives an oral presentation at the end of the second semester. Students pursuing both the Bachelor of Arts, Plan II, and a Bachelor of Science in Biomedical Engineering may use this course to fulfill the thesis requirements for the Bachelor of Arts, Plan II. Individual instruction for two semesters.
Pre/Corequisites: For 678A, admission to the major sequence in biomedical engineering and a University grade point average of at least 3.50; for 678B, a University grade point average of at least 3.50 and Biomedical Engineering 678A.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 379  Tissue Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to biomedical research in tissue engineering. Includes case studies of tissues and organs of the body, physiology and biology of tissue, pathologies of tissue, current clinical treatments, the role of engineers in development of new technologies to diagnose and treat pathologies, quantitative cellular and molecular techniques, and applications of synthetic and natural biomaterials. Only one of the following may be counted: Biomedical Engineering 379, Chemical Engineering 339T, 379 (Topic: Cell and Tissue Engineering). Three lecture hours a week for one semester.
Pre/Corequisites: Biomedical Engineering 352 and 365S with a grade of at least C- in each.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 679H  Undergraduate Honors Thesis  6 Hours  

0 Lecture Hours  0 Lab Hours  
Research performed during two consecutive semesters under the supervision of an engineering faculty member; topics are selected jointly by the student and the faculty member with approval by the director of the Engineering Honors Program. The student makes an oral presentation and writes a thesis. Students pursuing both the Bachelor of Arts, Plan II, and a bachelor's degree in engineering may use this course to fulfill the thesis requirement for the Bachelor of Arts, Plan II. Individual instruction for two semesters.
Pre/Corequisites: For 679HA, enrollment in the Engineering Honors Program; for 679HB, Biomedical Engineering 679HA and enrollment in the Engineering Honors Program.  
Restrictions: Restricted to biomedical engineering majors.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Upper Division  

BME 180J, 380J  Topics in the Fundamentals of Biomedical Engineering  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
One or three lecture hours a week for one semester, or as required by the topic.
Pre/Corequisites: Graduate standing.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Doctoral  
Topic 1: Mathematical Modeling in Biomedical Engineering. Conservation of mass, momentum, energy, and charge; first and second laws of thermodynamics; first- and second-order differential equations; nonlinear differential equations; partial differential equations as applied to biomedical engineering problems.

Topic 2: Quantitative Systems Physiology and Pathophysiology. Modeling of physiological systems from the molecular and cellular levels to the systems level; focus on the neuromuscular and cardiovascular systems. Additional prerequisite: An undergraduate physiology course or the equivalent, and consent of instructor.

Topic 3: Principles of Biomeasurement. Principles of signal measurement in the biomedical field; survey of transducers used for chemical, mechanical, electrical, and thermal biomedical measurements; analysis of how signals are converted into digital form; analysis of noise; aliasing; data storage.

Topic 4: Fields, Forces, and Flows. Introduction to mathematical models that integrate different energy domains and length scales, with an emphasis on the coupling between them. Additional prerequisite: Biomedical Engineering 380J (Topic 1) and 380J (Topic 2).

Topic 5: Biostatistics, Study Design, and Research Methodology. Principles for hypothesis testing; confidence limits; regression analysis; correlation; analysis of variance; experimental design and factorial analysis; discriminate analysis; applications of statistics. Additional prerequisite: An undergraduate probability theory course or the equivalent, and consent of instructor.

Topic 6: Analysis of Biomedical Engineering Systems I. Quantitative examination of the cardiovascular and respiratory systems from the cell to system levels. Presents the cardiovascular and respiratory systems in three phases: (1) anatomy and physiology; (2) energetics (thermodynamics), cellular processes, and engineering analysis; and (3) engineered devices, instrumentation, and imaging for therapeutics and diagnosis. Additional prerequisite: A course in physiology, proficiency in MATLAB, and consent of the graduate adviser.

Topic 7: Analysis of Biomedical Engineering Systems II. Computational techniques used in biomedical engineering. Students propose and conduct an engineering design study relevant to a selected medical problem. Additional prerequisite: Biomedical Engineering 380J (Topic 6).

Topic 8: Mathematical Methods for Biomedical Engineering. Analyze common mathematical techniques useful for biomedical engineering. Utilize vector calculus, linear algebra, Fourier and Laplace Transforms, and ordinary and partial differential equations. Explore common MATLAB (or Python) functions and manipulations for computationally implementing these mathematical techniques in biomedical engineering applications. Biomedical Engineering 380J (Topic: Mathematical Methods for BME) and 380J (Topic 8) may not both be counted. Restrictions: Required for first year biomedical engineering doctoral students.
  

BME 180J.1, 380J.1  Mathematical Modeling in Biomedical Engineering  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Conservation of mass, momentum, energy, and charge; first and second laws of thermodynamics; first- and second-order differential equations; nonlinear differential equations; partial differential equations as applied to biomedical engineering problems.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 180J.2, 380J.2  Quantitative Systems Physiology and Pathophysiology  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Modeling of physiological systems from the molecular and cellular levels to the systems level; focus on the neuromuscular and cardiovascular systems.
Pre/Corequisites: An undergraduate physiology course or the equivalent, and consent of instructor.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 180J.3, 380J.3  Principles of Biomeasurement  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Principles of signal measurement in the biomedical field; survey of transducers used for chemical, mechanical, electrical, and thermal biomedical measurements; analysis of how signals are converted into digital form; analysis of noise; aliasing; data storage.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 180J.4, 380J.4  Fields, Forces, and Flows  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Introduction to mathematical models that integrate different energy domains and length scales, with an emphasis on the coupling between them.
Pre/Corequisites: Biomedical Engineering 380J (Topic 1) and 380J (Topic 2).  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 180J.5, 380J.5  Biostatistics, Study Design, and Research Methodology  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Principles for hypothesis testing; confidence limits; regression analysis; correlation; analysis of variance; experimental design and factorial analysis; discriminate analysis; applications of statistics.
Pre/Corequisites: An undergraduate probability theory course or the equivalent, and consent of instructor.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 180J.6, 380J.6  Analysis of Biomedical Engineering Systems I  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Quantitative examination of the cardiovascular and respiratory systems from the cell to system levels. Presents the cardiovascular and respiratory systems in three phases: (1) anatomy and physiology; (2) energetics (thermodynamics), cellular processes, and engineering analysis; and (3) engineered devices, instrumentation, and imaging for therapeutics and diagnosis.
Pre/Corequisites: A course in physiology, proficiency in MATLAB, and consent of the graduate adviser.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 180J.7, 380J.7  Analysis of Biomedical Engineering Systems II  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Computational techniques used in biomedical engineering. Students propose and conduct an engineering design study relevant to a selected medical problem.
Pre/Corequisites: Biomedical Engineering 380J (Topic 6).  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 180J.8, 380J.8  Mathematical Methods for Biomedical Engineering  1,3 Hours  

1,3 Lecture Hours  0 Lab Hours  
Analyze common mathematical techniques useful for biomedical engineering. Utilize vector calculus, linear algebra, Fourier and Laplace Transforms, and ordinary and partial differential equations. Explore common MATLAB (or Python) functions and manipulations for computationally implementing these mathematical techniques in biomedical engineering applications. Biomedical Engineering 380J (Topic: Mathematical Methods for BME) and 380J (Topic 8) may not both be counted.
Restrictions: Required for first year biomedical engineering doctoral students.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 080M  Dual MD/PhD Program with UT Medical Branch  0 Hours  

0 Lecture Hours  0 Lab Hours  
Preclinical medical study at the University of Texas Medical Branch at Galveston. May not be taken concurrently with another course at the University of Texas at Austin.
Pre/Corequisites: Graduate standing and admission to the MD/PhD dual degree program in biomedical engineering.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J  Topics in Cell and Molecular Imaging  3 Hours  

3 Lecture Hours  0 Lab Hours  
Three lecture hours a week for one semester, or as required by the topic.
Pre/Corequisites: Graduate standing in engineering and consent of instructor; additional prerequisites vary with the topic.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Doctoral  
Topic 1: Laser-Tissue Interaction: Thermal. The thermal response of random media in interaction with laser irradiation. Calculation of the rate of heat production caused by direct absorption of the laser light, thermal damage, and ablation. Only one of the following may be counted: Biomedical Engineering 381J (Topic 1), Electrical and Computer Engineering 385J (Topic 9), Electrical Engineering 385J (Topic 9). Same as: ECE 385J.9

Topic 2: Laser-Tissue Interaction: Optical. The optical behavior of random media such as tissue in interaction with laser irradiation. Approximate transport equation methods to predict the absorption and scattering parameters of laser light inside tissue. Port-wine stain treatment; cancer treatment by photochemotherapy; and cardiovascular applications. Only one of the following may be counted: Biomedical Engineering 381J (Topic 2), Electrical and Computer Engineering 385J (Topic 16), Electrical Engineering 385J (Topic 16). Same as: ECE 385J.16

Topic 3: Imaging Signals and Systems. Physical principles and signal processing techniques used in thermographic, ultrasonic, and radiographic imaging, including image reconstruction from projections such as CT scanning, MRI, and millimeter wave determination of temperature profiles. Only one of the following may be counted: Biomedical Engineering 381J (Topic 3), Electrical and Computer Engineering 385J (Topic 18), Electrical Engineering 385J (Topic 18). Same as: ECE 385J.18

Topic 4: Optical Spectroscopy. Measurement and interpretation of spectra: steady-state and time-resolved absorption, fluorescence, phosphorescence, and Raman spectroscopy in the ultraviolet, visible, and infrared portions of the spectrum. Only one of the following may be counted: Biomedical Engineering 381J (Topic 4), Electrical and Computer Engineering 385J (Topic 23), Electrical Engineering 385J (Topic 23). Same as: ECE 385J.23

Topic 5: Therapeutic Heating. Engineering aspects of electromagnetic fields that have therapeutic applications: diathermy (short wave, microwave, and ultrasound), electrosurgery (thermal damage processes), stimulation of excitable tissue, and electrical safety. Only one of the following may be counted: Biomedical Engineering 381J (Topic 5), Electrical and Computer Engineering 385J (Topic 26), Electrical Engineering 385J (Topic 26). Same as: ECE 385J.26

Topic 6: Noninvasive Optical Tomography. Basic principles of optical tomographic imaging of biological materials for diagnostic or therapeutic applications. Optical-based tomographic imaging techniques including photothermal, photoacoustic, and coherent methodologies. Only one of the following may be counted: Biomedical Engineering 381J (Topic 6), Electrical and Computer Engineering 385J (Topic 28), Electrical Engineering 385J (Topic 28). Same as: ECE 385J.28

Topic 7: Digital Image and Video Processing. Digital image acquisition, processing, and analysis; algebraic and geometric image transformations; two-dimensional Fourier analysis; image filtering and coding. Additional prerequisite: Credit or registration for Biomedical Engineering 335 or Electrical Engineering 351K.

Topic 8: Functional Imaging Laboratory. Explores in vivo functional imaging, including aspects of imaging hardware and instrumentation, contrast agents, image processing, management of large imaging data sets, and applications of physiological modeling. Biomedical Engineering 381J (Topic: Functional Imaging Laboratory) and 381J (Topic 8) may not both be counted. Three lecture hours a week for one semester. Additional hours to be arranged. Additional prerequisite: Graduate standing in engineering.

Topic 9: Fundamentals of Biomedical Optical Imaging. Fundamentals of the interaction of light with tissue for the purpose of imaging and treatment of disease. Focuses on quantitative modeling of tissue optical properties, light propagation in the tissue, heat transfer of laser irradiated tissue, and thermal damage models. Includes discussion of applications in laser surgery, pulse oximetry, and disease diagnosis using spectroscopy. Biomedical Engineering 381J (Topic: Fundamentals of Biomedical Optical Imaging) and 381J (Topic 9) may not both be counted.

Topic 10: Optics and Lasers. Fundamentals of geometric and physical optics, interaction of light with matter, spectroscopy, and laser and electro-optics applications. Biomedical Engineering 381J (Topic: Optics and Lasers) and 381J (Topic 10) may not both be counted.

Topic 11: Medical Imaging. Biomedical Engineering 381J (Topic: Medical Imaging) and 381J (Topic 11) may not both be counted.

Topic 12: Optical Design. The principles of optical design for imaging and laser delivery systems are given. Students develop and test designs using a commercial optical design software package. Biomedical Engineering 381J (Topic: Optical Design) and 381J (Topic 12) may not both be counted.

Topic 13: Fluorescence Micro- and Spectroscopy. Fundamentals of fluorescence microscopy, spectroscopy, and techniques; single-molecule detection; advanced microscopy, including multi-photon microscopy, super-resolution imaging, and molecular tracking. Other subjects include metal-enhanced fluorescence, optogenetics, nanomedicine and microfluidics. Biomedical Engineering 381J (Topic: Fluorescence Micro-/Spectroscopy) and 381J (Topic 13) may not both be counted. Additional prerequisite: Understanding of biochemistry and biology; lab experience using microscopic technology and tools.

Topic 14: Digital Video. Examine video sampling and transform; video (retinal and cortical) filters; motion detection and estimation; statistical models of videos; neuroscience of video perception; natural video statistics; modern video compression standards; video quality prediction; video denoising; active contour models; and video saliency. Only one of the following may be counted: Biomedical Engineering 381J (Topic: Digital Video), 381J (Topic 14), Electrical and Computer Engineering 381K (Topic 16), Electrical Engineering 381K (Topic 16), 381V (Topic: Digital Video). Same as: ECE 381K.16

Topic 15: Imaging Clinical Immersion. Identify current unmet clinical needs via close interaction with healthcare professionals and patients. Explore biomedical imaging across the healthcare enterprise. Biomedical Engineering 381J (Topic 15) and 385J (Topic: Imaging Clinical Immersion) may not both be counted.
  

BME 381J.1  Laser-Tissue Interaction: Thermal  3 Hours  

3 Lecture Hours  0 Lab Hours  
The thermal response of random media in interaction with laser irradiation. Calculation of the rate of heat production caused by direct absorption of the laser light, thermal damage, and ablation. Only one of the following may be counted: Biomedical Engineering 381J (Topic 1), Electrical and Computer Engineering 385J (Topic 9), Electrical Engineering 385J (Topic 9).
Same as: ECE 385J.9  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.10  Optics and Lasers  3 Hours  

3 Lecture Hours  0 Lab Hours  
Fundamentals of geometric and physical optics, interaction of light with matter, spectroscopy, and laser and electro-optics applications. Biomedical Engineering 381J (Topic: Optics and Lasers) and 381J (Topic 10) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.11  Medical Imaging  3 Hours  

3 Lecture Hours  0 Lab Hours  
Biomedical Engineering 381J (Topic: Medical Imaging) and 381J (Topic 11) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.12  Optical Design  3 Hours  

3 Lecture Hours  0 Lab Hours  
The principles of optical design for imaging and laser delivery systems are given. Students develop and test designs using a commercial optical design software package. Biomedical Engineering 381J (Topic: Optical Design) and 381J (Topic 12) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.13  Fluorescence Micro- and Spectroscopy  3 Hours  

3 Lecture Hours  0 Lab Hours  
Fundamentals of fluorescence microscopy, spectroscopy, and techniques; single-molecule detection; advanced microscopy, including multi-photon microscopy, super-resolution imaging, and molecular tracking. Other subjects include metal-enhanced fluorescence, optogenetics, nanomedicine and microfluidics. Biomedical Engineering 381J (Topic: Fluorescence Micro-/Spectroscopy) and 381J (Topic 13) may not both be counted.
Pre/Corequisites: Understanding of biochemistry and biology; lab experience using microscopic technology and tools.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.14  Digital Video  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine video sampling and transform; video (retinal and cortical) filters; motion detection and estimation; statistical models of videos; neuroscience of video perception; natural video statistics; modern video compression standards; video quality prediction; video denoising; active contour models; and video saliency. Only one of the following may be counted: Biomedical Engineering 381J (Topic: Digital Video), 381J (Topic 14), Electrical and Computer Engineering 381K (Topic 16), Electrical Engineering 381K (Topic 16), 381V (Topic: Digital Video).
Same as: ECE 381K.16  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.15  Imaging Clinical Immersion  3 Hours  

3 Lecture Hours  0 Lab Hours  
Identify current unmet clinical needs via close interaction with healthcare professionals and patients. Explore biomedical imaging across the healthcare enterprise. Biomedical Engineering 381J (Topic 15) and 385J (Topic: Imaging Clinical Immersion) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.2  Laser-Tissue Interaction: Optical  3 Hours  

3 Lecture Hours  0 Lab Hours  
The optical behavior of random media such as tissue in interaction with laser irradiation. Approximate transport equation methods to predict the absorption and scattering parameters of laser light inside tissue. Port-wine stain treatment; cancer treatment by photochemotherapy; and cardiovascular applications. Only one of the following may be counted: Biomedical Engineering 381J (Topic 2), Electrical and Computer Engineering 385J (Topic 16), Electrical Engineering 385J (Topic 16).
Same as: ECE 385J.16  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.3  Imaging Signals and Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Physical principles and signal processing techniques used in thermographic, ultrasonic, and radiographic imaging, including image reconstruction from projections such as CT scanning, MRI, and millimeter wave determination of temperature profiles. Only one of the following may be counted: Biomedical Engineering 381J (Topic 3), Electrical and Computer Engineering 385J (Topic 18), Electrical Engineering 385J (Topic 18).
Same as: ECE 385J.18  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.4  Optical Spectroscopy  3 Hours  

3 Lecture Hours  0 Lab Hours  
Measurement and interpretation of spectra: steady-state and time-resolved absorption, fluorescence, phosphorescence, and Raman spectroscopy in the ultraviolet, visible, and infrared portions of the spectrum. Only one of the following may be counted: Biomedical Engineering 381J (Topic 4), Electrical and Computer Engineering 385J (Topic 23), Electrical Engineering 385J (Topic 23).
Same as: ECE 385J.23  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.5  Therapeutic Heating  3 Hours  

3 Lecture Hours  0 Lab Hours  
Engineering aspects of electromagnetic fields that have therapeutic applications: diathermy (short wave, microwave, and ultrasound), electrosurgery (thermal damage processes), stimulation of excitable tissue, and electrical safety. Only one of the following may be counted: Biomedical Engineering 381J (Topic 5), Electrical and Computer Engineering 385J (Topic 26), Electrical Engineering 385J (Topic 26).
Same as: ECE 385J.26  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.6  Noninvasive Optical Tomography  3 Hours  

3 Lecture Hours  0 Lab Hours  
Basic principles of optical tomographic imaging of biological materials for diagnostic or therapeutic applications. Optical-based tomographic imaging techniques including photothermal, photoacoustic, and coherent methodologies. Only one of the following may be counted: Biomedical Engineering 381J (Topic 6), Electrical and Computer Engineering 385J (Topic 28), Electrical Engineering 385J (Topic 28).
Same as: ECE 385J.28  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.7  Digital Image and Video Processing  3 Hours  

3 Lecture Hours  0 Lab Hours  
Digital image acquisition, processing, and analysis; algebraic and geometric image transformations; two-dimensional Fourier analysis; image filtering and coding.
Pre/Corequisites: Credit or registration for Biomedical Engineering 335 or Electrical Engineering 351K.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.8  Functional Imaging Laboratory  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explores in vivo functional imaging, including aspects of imaging hardware and instrumentation, contrast agents, image processing, management of large imaging data sets, and applications of physiological modeling. Biomedical Engineering 381J (Topic: Functional Imaging Laboratory) and 381J (Topic 8) may not both be counted. Three lecture hours a week for one semester. Additional hours to be arranged.
Pre/Corequisites: Graduate standing in engineering.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 381J.9  Fundamentals of Biomedical Optical Imaging  3 Hours  

3 Lecture Hours  0 Lab Hours  
Fundamentals of the interaction of light with tissue for the purpose of imaging and treatment of disease. Focuses on quantitative modeling of tissue optical properties, light propagation in the tissue, heat transfer of laser irradiated tissue, and thermal damage models. Includes discussion of applications in laser surgery, pulse oximetry, and disease diagnosis using spectroscopy. Biomedical Engineering 381J (Topic: Fundamentals of Biomedical Optical Imaging) and 381J (Topic 9) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 681M  Normal Body Structure and Function  6 Hours  

6 Lecture Hours  0 Lab Hours  
Exploration of the structure and function of the human body at all levels of organization, from molecular and cellular to the integrated function of multiple organ systems attempting to maintain homeostasis. Emphasis on wellness and normal structure/function, in addition to the mechanistic disruptions that cause illness as well as the scientific rationale for methods to diagnose and treat selected diseases. Six lecture hours a week for one semester.
Restrictions: Restricted to students in the Master of Science in Engineering and Doctor of Medicine dual-degree program.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Master's  

BME 382J  Topics in Cellular and Biomolecular Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Three lecture hours a week for one semester, or as required by the topic.
Pre/Corequisites: Graduate standing in engineering and consent of instructor.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Doctoral  
Topic 1: Cell and Tissue Engineering. Use of case studies to explore pathologies of tissue, current clinical treatment, and the role of engineers in developing new technologies to diagnose and treat these pathologies. Emphasis on the use of quantitative cellular and molecular techniques. Applications of synthetic and natural biomaterials. Additional prerequisite: Quantitative physiology or pathophysiology course.

Topic 2: Introduction to Biochemical Engineering. Microorganisms in chemical and biochemical synthesis; genetic manipulation of cells by classical and recombinant DNA techniques; enzyme technology; design of bioreactors and microbial fermentations; and separations of biological products.

Topic 3: Molecular Sensors and Nanodevices for Biomedical Engineering Introduction to a variety of methods used to detect biological molecules with optical and electrical transduction mechanisms. Covers the classical approaches to biosensors for the detection of specific molecules in biological systems.

Topic 4: Advanced Engineering Biomaterials. Overview of biomaterials, including prosthetics, ceramics, metal implants, and polymers, with specific emphasis on properties and applications. The immunology of material-tissue interactions and the issues of biocompatibility.

Topic 5: Structured Surfaces, Fabrication, Characterization, and Application. Introduction to fabrication and characterization techniques used to create and analyze microstructured and nanostructured surfaces for biomedical and biotechnology applications. Focuses on the use of self-assembly processes for the fabrication of biological functionality in surface structures.

Topic 6: Biopolymers and Drug/Gene Delivery. Biomedical polymers and their applications in drug delivery and gene therapy. Emphasis on parenteral, mucosal, and topical delivery of biomolecules, and the role of polymers in genetic therapy and DNA vaccination.

Topic 7: Cellular and Molecular Biomechanics. Introduction to the concepts needed to understand and work in the emerging field of cellular and molecular biomechanics. Examination of dynamic interplay between chemical, thermal, and physical forces in determining the mechanics of cells/tissues and their molecular components. Biomedical Engineering 382J (Topic: Cellular and Molecular Biomechanics) and 382J (Topic 7) may not both be counted. Three lectures hours a week for one semester, with additional hours to be arranged. Additional prerequisite: Graduate standing; and coursework in calculus, physics, solid mechanics, and basic chemical/biological principles.

Topic 8: Molecular Biophysics: Measurements and Methods. In-depth study and development of intuition for thermodynamics and mechanics and application of understanding to molecular-scale problems in cell biology and biomedical engineering. Focus on increasing students' familiarity with modern methods of biophysical measurement, their strengths and limitations, and how they are being applied to address current research problems. Biomedical Engineering 382J (Topic: Molecular Biophysics: Measurements and Methods) and 382J (Topic 8) may not both be counted. Additional prerequisite: Undergraduate biology, calculus, chemistry, and physics is recommended.

Topic 9: Biomimetic Design and Engineering. Introduction to biomimetic reverse engineering, including the weaknesses of animal models to predict human physiology, microphysiological systems, the potential of human organs on chips to accelerate drug development processes, pharmaceutical preclinical testing requirements, human microbiome, disease models to study pathophysiology, and related subjects. Biomedical Engineering 382J (Topic: Biomimetic Design and Engineering) and 382J (Topic 9) may not both be counted.

Topic 10: Immune Engineering. Introduction to the concept of immune engineering. Discussion of vaccine design, cancer immunotherapy, genomics, infection, auto-immune diseases and emerging tools and methodologies. Biomedical Engineering 382J (Topic: Immune Engineering) and 382J (Topic 10) may not both be counted. Additional prerequisite: Understanding of biology.

Topic 11: Polymer and Bioconjugate Chemistry. Examine principles of polymeric biomaterials and bioconjugate chemistry with an emphasis on synthetic strategies to achieve specific properties. Includes characterization methods of polymers and bioconjugates as a function of chemical composition, as well as tissue engineering and drug delivery applications as case studies of the biomaterial design process. Biomedical Engineering 382J (Topic: Polymer/Bioconjugate Chem) and 382J (Topic 11) may not both be counted. Three lecture hours a week for one semester.

Topic 12: Biological Responses to Medical Devices. Examine key challenges in the development and assessment of biomaterials used in medical devices, including common biological responses elicited by biomaterials and the impact of these responses on material performance. Includes material surface properties, modification, and characterization; protein/cell interactions with materials; biocompatibility, inflammation and wound healing, cell-mediated biodegradation of materials; thrombosis, infection and calcification of medical devices. Biomedical Engineering 382J (Topic: Biol Responses to Medical Dev) and 382J (Topic 12) may not both be counted.

Topic 13: Delivery of Therapeutic Agents. Explore molecular, biological, chemical, and mathematical fundamentals of the use of macromolecular carriers for the release of small and high molecular weight therapeutic agents in vitro and in vivo. Examine design and advanced techniques of protein, peptide, antibodies, and gene therapy. Discuss targeted delivery, mucoadhesive therapy, and theranostics, as well as advanced biomedical devices for treatment of diseases. Biomedical Engineering 382J (Topic: Delivery of Therapeutic Agents) and 382J (Topic 13) may not both be counted.

Topic 14: Nanomedicine. Explore the fundamental properties, synthesis and characterization of nanomaterials, including their applications in nanomedicine. Discuss micro- and nano-particles for drug delivery and imaging, microfluidics for in vitro diagnostics and biological systems modeling, and nanomaterials and platforms for biological applications. Examine biomedical applications such as cancer, cardiovascular disease, and infectious diseases. Biomedical Engineering 382J (Topic: Nanomedicine) and 382J (Topic 14) may not both be counted.

Topic 15: Matrices, Organoids, and Microphysiological Systems. Explore current technologies and scientific literature seeking to construct human-relevant, in vitro systems representing tissues, organs, and disease physiologies as platforms for development of new therapies. Focus on how concepts in biomaterials, stem cell biology, microfluidics, additive manufacturing, and biosensing are integrated to create such platforms. Biomedical Engineering 382J (Topic: Matrices/Organs/Microphys Sys) and 382J (Topic 15) may not both be counted.
  

BME 382J.1  Cell and Tissue Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Use of case studies to explore pathologies of tissue, current clinical treatment, and the role of engineers in developing new technologies to diagnose and treat these pathologies. Emphasis on the use of quantitative cellular and molecular techniques. Applications of synthetic and natural biomaterials.
Pre/Corequisites: Quantitative physiology or pathophysiology course.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.10  Immune Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to the concept of immune engineering. Discussion of vaccine design, cancer immunotherapy, genomics, infection, auto-immune diseases and emerging tools and methodologies. Biomedical Engineering 382J (Topic: Immune Engineering) and 382J (Topic 10) may not both be counted.
Pre/Corequisites: Understanding of biology.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.11  Polymer and Bioconjugate Chemistry  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine principles of polymeric biomaterials and bioconjugate chemistry with an emphasis on synthetic strategies to achieve specific properties. Includes characterization methods of polymers and bioconjugates as a function of chemical composition, as well as tissue engineering and drug delivery applications as case studies of the biomaterial design process. Biomedical Engineering 382J (Topic: Polymer/Bioconjugate Chem) and 382J (Topic 11) may not both be counted. Three lecture hours a week for one semester.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.12  Biological Responses to Medical Devices  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine key challenges in the development and assessment of biomaterials used in medical devices, including common biological responses elicited by biomaterials and the impact of these responses on material performance. Includes material surface properties, modification, and characterization; protein/cell interactions with materials; biocompatibility, inflammation and wound healing, cell-mediated biodegradation of materials; thrombosis, infection and calcification of medical devices. Biomedical Engineering 382J (Topic: Biol Responses to Medical Dev) and 382J (Topic 12) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.13  Delivery of Therapeutic Agents  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore molecular, biological, chemical, and mathematical fundamentals of the use of macromolecular carriers for the release of small and high molecular weight therapeutic agents in vitro and in vivo. Examine design and advanced techniques of protein, peptide, antibodies, and gene therapy. Discuss targeted delivery, mucoadhesive therapy, and theranostics, as well as advanced biomedical devices for treatment of diseases. Biomedical Engineering 382J (Topic: Delivery of Therapeutic Agents) and 382J (Topic 13) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.14  Nanomedicine  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore the fundamental properties, synthesis and characterization of nanomaterials, including their applications in nanomedicine. Discuss micro- and nano-particles for drug delivery and imaging, microfluidics for in vitro diagnostics and biological systems modeling, and nanomaterials and platforms for biological applications. Examine biomedical applications such as cancer, cardiovascular disease, and infectious diseases. Biomedical Engineering 382J (Topic: Nanomedicine) and 382J (Topic 14) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.15  Matrices, Organoids, and Microphysiological Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore current technologies and scientific literature seeking to construct human-relevant, in vitro systems representing tissues, organs, and disease physiologies as platforms for development of new therapies. Focus on how concepts in biomaterials, stem cell biology, microfluidics, additive manufacturing, and biosensing are integrated to create such platforms. Biomedical Engineering 382J (Topic: Matrices/Organs/Microphys Sys) and 382J (Topic 15) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.2  Introduction to Biochemical Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Microorganisms in chemical and biochemical synthesis; genetic manipulation of cells by classical and recombinant DNA techniques; enzyme technology; design of bioreactors and microbial fermentations; and separations of biological products.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.3  Molecular Sensors and Nanodevices for Biomedical Engineering Applications  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to a variety of methods used to detect biological molecules with optical and electrical transduction mechanisms. Covers the classical approaches to biosensors for the detection of specific molecules in biological systems.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.4  Advanced Engineering Biomaterials  3 Hours  

3 Lecture Hours  0 Lab Hours  
Overview of biomaterials, including prosthetics, ceramics, metal implants, and polymers, with specific emphasis on properties and applications. The immunology of material-tissue interactions and the issues of biocompatibility.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.5  Structured Surfaces, Fabrication, Characterization, and Application  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to fabrication and characterization techniques used to create and analyze microstructured and nanostructured surfaces for biomedical and biotechnology applications. Focuses on the use of self-assembly processes for the fabrication of biological functionality in surface structures.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.6  Biopolymers and Drug/Gene Delivery  3 Hours  

3 Lecture Hours  0 Lab Hours  
Biomedical polymers and their applications in drug delivery and gene therapy. Emphasis on parenteral, mucosal, and topical delivery of biomolecules, and the role of polymers in genetic therapy and DNA vaccination.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.7  Cellular and Molecular Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to the concepts needed to understand and work in the emerging field of cellular and molecular biomechanics. Examination of dynamic interplay between chemical, thermal, and physical forces in determining the mechanics of cells/tissues and their molecular components. Biomedical Engineering 382J (Topic: Cellular and Molecular Biomechanics) and 382J (Topic 7) may not both be counted. Three lectures hours a week for one semester, with additional hours to be arranged.
Pre/Corequisites: Graduate standing; and coursework in calculus, physics, solid mechanics, and basic chemical/biological principles.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.8  Molecular Biophysics: Measurements and Methods  3 Hours  

3 Lecture Hours  0 Lab Hours  
In-depth study and development of intuition for thermodynamics and mechanics and application of understanding to molecular-scale problems in cell biology and biomedical engineering. Focus on increasing students' familiarity with modern methods of biophysical measurement, their strengths and limitations, and how they are being applied to address current research problems. Biomedical Engineering 382J (Topic: Molecular Biophysics: Measurements and Methods) and 382J (Topic 8) may not both be counted.
Pre/Corequisites: Undergraduate biology, calculus, chemistry, and physics is recommended.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382J.9  Biomimetic Design and Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to biomimetic reverse engineering, including the weaknesses of animal models to predict human physiology, microphysiological systems, the potential of human organs on chips to accelerate drug development processes, pharmaceutical preclinical testing requirements, human microbiome, disease models to study pathophysiology, and related subjects. Biomedical Engineering 382J (Topic: Biomimetic Design and Engineering) and 382J (Topic 9) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 382M, 682M  Biodesign: Needs Identification  3,6 Hours  

3,6 Lecture Hours  0 Lab Hours  
Identify concrete clinical needs via clinical immersion experience with healthcare professionals and patients. Apply engineering design methodologies to identify clinical needs based upon the most meaningful problems observed. Biomedical Engineering 682M and 385J (Topic: Biodsgn: Needs Identification) may not both be counted. For each semester hour of credit earned, the equivalent of one lecture hour a week for one semester.
Pre/Corequisites: Consent of instructor.  
Restrictions: Restricted to students in the Clinical Innovation and Design Program.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Master's  

BME 383J  Topics in Computational Biomedical Engineering and Bioinformatics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Three lecture hours a week for one semester, or as required by the topic.
Pre/Corequisites: Graduate standing in engineering and consent of instructor; additional prerequisites may vary with the topic.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Doctoral  
Topic 1: Network Thermodynamics in Biophysics. Modeling and simulation methods for nonlinear biological processes, including coupling across multienergy domains; practical implementation by bond graph techniques. Additional prerequisite: Mechanical Engineering 344 or consent of instructor.

Topic 2: Musculoskeletal Biomechanics. Synthesis of properties of the musculotendon and skeletal systems to construct detailed computer models that quantify human performance and muscular coordination. Additional prerequisite: Mathematics 341 and Kinesiology 395 (Topic 36: Biomechanics of Human Movement).

Topic 3: Introduction to Computational Oncology. Computational techniques commonly used in modeling various aspects of cancer at multiple spatial and temporal scales. Exploration of how computational modeling offers unique and complementary information to traditional methods of cancer research. Emphasis on the integration of theory and experiment while identifying the current barriers preventing computational modeling from having a broader impact on both cancer biology and clinical oncology. Only one of the following may be counted: Biomedical Engineering 383J (Topic: Introduction to Computational Oncology), Biomedical Engineering 383J (Topic 3), Computational Science, Engineering, and Mathematics 397 (Topic: Introduction to Computational Oncology).

Topic 4: Biomechanics of Human Movement. Same as: KIN 395.36 Additional prerequisite: Kinesiology 326K, two semesters of calculus, one semester of college physics (mechanics), and consent of instructor.

Topic 5: Introduction to Nonlinear Dynamics in Biological Systems. Basic concepts of nonlinear mathematics and their application to biological systems. Same as: KIN 395.63 Additional prerequisite: Two semesters of college-level calculus and consent of instructor.

Topic 6: Genomic Signal Processing and Bioinformatics. Exploration of technologies such as sequencing, DNA microarrays, and protein mass spectrometry for high throughput acquisition of molecular biological data. Mathematical analysis and modeling of these data, and biological and medical predictions made by these analyses and models. Additional prerequisite: Knowledge of Mathematica, MATLAB, or a programming language.

Topic 7: Data Mining. Analyzing large data sets for interesting and useful information; online analytical processing, finding association rules, clustering, classification, and function approximation; scalability of algorithms and real-life applications.

Topic 8: Systems Biology. The biological function of genetic and biochemical networks from a quantitative perspective. Students use mathematical tools to model network modules, such as biological switches, oscillators, and amplifiers. Discusses recent papers on a variety of biological problems that can be addressed with a systems biology approach. Additional prerequisite: Biology 311C and Mathematics 427K; an introductory course in biochemistry, and knowledge of MATLAB, are recommended.

Topic 9: Computational Methods for Biomedical Engineers. Study of and hands-on experiences with computational methods commonly employed in biomedical engineering research. Biomedical Engineering 383J (Topic: Computational Methods for Biomedical Engineers I) and 383J (Topic 9) may not both be counted. Three lecture hours a week for one semester. Additional prerequisite: Graduate standing in engineering.

Topic 10: Computational Biomolecular Engineering. Provides an introduction to the principles and applications of biomolecular modeling and simulation, including the theoretical background of molecular thermodynamics and molecular mechanics, major simulation/computational techniques and commonly used software tools. Biomedical Engineering 383J (Topic: Computational Biomolecular Engineering) and 383J (Topic 10) may not both be counted. Additional prerequisite: Undergraduate biochemistry coursework, and thermodynamics or physical chemistry coursework; or consent of instructor.

Topic 11: Dynamical Modeling of Biological Signaling and Regulatory Systems. Introduction to various approaches currently used for modeling and simulating cellular signal transduction, metabolic, and gene regulatory networks. Biomedical Engineering 383J (Topic: Dynamical Modeling of Biological Signaling and Regulatory Systems) and 383J (Topic 11) may not both be counted. Additional prerequisite: Understanding of biochemistry and biology; familiarity with a programming environment.

Topic 12: Computational Modeling in Bioengineering and Medicine. Comprehensive introduction to methods used in simulation of biological systems and processes. Emphasis on selected applications from single channels, cells, and tissues up to whole organs. Only one of the following may be counted: Biomedical Engineering 383J (Topic 12), 385J (Topic: Comptl Mdlng Bioengr and Med), Computational Science, Engineering, and Mathematics 397 (Topic: Comptl Mdlng in Bioengr & Med).

Topic 13: Introduction to Mathematical and Physical Biology. Introduction to common mathematical and physical techniques used in modeling various aspects of biology at multiple spatial and temporal scales. Explore the integration of theory and experiment while identifying the current barriers preventing computational modeling from having a broader impact in biology. Only one of the following may be counted: Biomedical Engineering 383J (Topic: Intro Mathematical & Phys Bio), 383J (Topic 13), Computational Science, Engineering, and Mathematics 397 (Topic: Intro Mathematical & Phys Biol).

Topic 14: Mathematical Physiology. Explore mathematical modeling in physiology, how physiological problems can be formulated and modeled, and how such models give rise to interesting and challenging functional features. Examine several exemplar physiological systems. Discuss the mathematical aspects of growth and remodeling in living systems, an area unique to living systems. Only one of the following may be counted: Biomedical Engineering 383J (Topic: Mathematical Physiology), 383J (Topic 14), Computational Science, Engineering, and Mathematics 397 (Topic: Mathematical Physiology), 397 (Topic 9). Same as: CSE 397.9
  

BME 383J.1  Network Thermodynamics in Biophysics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Modeling and simulation methods for nonlinear biological processes, including coupling across multienergy domains; practical implementation by bond graph techniques.
Pre/Corequisites: Mechanical Engineering 344 or consent of instructor.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.10  Computational Biomolecular Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Provides an introduction to the principles and applications of biomolecular modeling and simulation, including the theoretical background of molecular thermodynamics and molecular mechanics, major simulation/computational techniques and commonly used software tools. Biomedical Engineering 383J (Topic: Computational Biomolecular Engineering) and 383J (Topic 10) may not both be counted.
Pre/Corequisites: Undergraduate biochemistry coursework, and thermodynamics or physical chemistry coursework; or consent of instructor.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.11  Dynamical Modeling of Biological Signaling and Regulatory Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to various approaches currently used for modeling and simulating cellular signal transduction, metabolic, and gene regulatory networks. Biomedical Engineering 383J (Topic: Dynamical Modeling of Biological Signaling and Regulatory Systems) and 383J (Topic 11) may not both be counted.
Pre/Corequisites: Understanding of biochemistry and biology; familiarity with a programming environment.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.12  Computational Modeling in Bioengineering and Medicine  3 Hours  

3 Lecture Hours  0 Lab Hours  
Comprehensive introduction to methods used in simulation of biological systems and processes. Emphasis on selected applications from single channels, cells, and tissues up to whole organs. Only one of the following may be counted: Biomedical Engineering 383J (Topic 12), 385J (Topic: Comptl Mdlng Bioengr and Med), Computational Science, Engineering, and Mathematics 397 (Topic: Comptl Mdlng in Bioengr & Med).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.13  Introduction to Mathematical and Physical Biology  3 Hours  

3 Lecture Hours  0 Lab Hours  
Introduction to common mathematical and physical techniques used in modeling various aspects of biology at multiple spatial and temporal scales. Explore the integration of theory and experiment while identifying the current barriers preventing computational modeling from having a broader impact in biology. Only one of the following may be counted: Biomedical Engineering 383J (Topic: Intro Mathematical & Phys Bio), 383J (Topic 13), Computational Science, Engineering, and Mathematics 397 (Topic: Intro Mathematical & Phys Biol).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.14  Mathematical Physiology  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore mathematical modeling in physiology, how physiological problems can be formulated and modeled, and how such models give rise to interesting and challenging functional features. Examine several exemplar physiological systems. Discuss the mathematical aspects of growth and remodeling in living systems, an area unique to living systems. Only one of the following may be counted: Biomedical Engineering 383J (Topic: Mathematical Physiology), 383J (Topic 14), Computational Science, Engineering, and Mathematics 397 (Topic: Mathematical Physiology), 397 (Topic 9).
Same as: CSE 397.9  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.2  Musculoskeletal Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Synthesis of properties of the musculotendon and skeletal systems to construct detailed computer models that quantify human performance and muscular coordination.
Pre/Corequisites: Mathematics 341 and Kinesiology 395 (Topic 36: Biomechanics of Human Movement).  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.3  Introduction to Computational Oncology  3 Hours  

3 Lecture Hours  0 Lab Hours  
Computational techniques commonly used in modeling various aspects of cancer at multiple spatial and temporal scales. Exploration of how computational modeling offers unique and complementary information to traditional methods of cancer research. Emphasis on the integration of theory and experiment while identifying the current barriers preventing computational modeling from having a broader impact on both cancer biology and clinical oncology. Only one of the following may be counted: Biomedical Engineering 383J (Topic: Introduction to Computational Oncology), Biomedical Engineering 383J (Topic 3), Computational Science, Engineering, and Mathematics 397 (Topic: Introduction to Computational Oncology).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.4  Biomechanics of Human Movement  3 Hours  

3 Lecture Hours  0 Lab Hours  
Same as: KIN 395.36  
Pre/Corequisites: Kinesiology 326K, two semesters of calculus, one semester of college physics (mechanics), and consent of instructor.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.5  Introduction to Nonlinear Dynamics in Biological Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Basic concepts of nonlinear mathematics and their application to biological systems.
Same as: KIN 395.63  
Pre/Corequisites: Two semesters of college-level calculus and consent of instructor.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.7  Data Mining  3 Hours  

3 Lecture Hours  0 Lab Hours  
Analyzing large data sets for interesting and useful information; online analytical processing, finding association rules, clustering, classification, and function approximation; scalability of algorithms and real-life applications.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.8  Systems Biology  3 Hours  

3 Lecture Hours  0 Lab Hours  
The biological function of genetic and biochemical networks from a quantitative perspective. Students use mathematical tools to model network modules, such as biological switches, oscillators, and amplifiers. Discusses recent papers on a variety of biological problems that can be addressed with a systems biology approach.
Pre/Corequisites: Biology 311C and Mathematics 427K; an introductory course in biochemistry, and knowledge of MATLAB, are recommended.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383J.9  Computational Methods for Biomedical Engineers  3 Hours  

3 Lecture Hours  0 Lab Hours  
Study of and hands-on experiences with computational methods commonly employed in biomedical engineering research. Biomedical Engineering 383J (Topic: Computational Methods for Biomedical Engineers I) and 383J (Topic 9) may not both be counted. Three lecture hours a week for one semester.
Pre/Corequisites: Graduate standing in engineering.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 383M, 683M  Biodesign: Entrepreneurship  3,6 Hours  

3,6 Lecture Hours  0 Lab Hours  
Develop a team project in biomedical engineering with emphasis on detailed design and prototyping. Prepare a business plan designed to bring product to market or use in clinical practice. Biomedical Engineering 683M and 385J (Topic: Biodesign: Entrepreneurship) may not both be counted. For each semester hour of credit earned, the equivalent of one lecture hour a week for one semester.
Pre/Corequisites: Consent of instructor and Biomedical Engineering 682M with a grade of at least C-.  
Restrictions: Restricted to students in the Clinical Innovation and Design Program.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Master's  

BME 384J  Topics in Instrumentation  3 Hours  

3 Lecture Hours  0 Lab Hours  
Three lecture hours a week for one semester, or as required by the topic.
Pre/Corequisites: Graduate standing in engineering and consent of instructor; additional prerequisites vary with the topic.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Doctoral  
Topic 1: Biomedical Instrumentation I. Application of electrical engineering techniques to analysis and instrumentation in biological sciences: pressure, flow, temperature measurement; bioelectrical signals; pacemakers; ultrasonics; electrical safety; electrotherapeutics. Only one of the following may be counted: Biomedical Engineering 384J (Topic 1), Electrical and Computer Engineering 385J (Topic 31), Electrical Engineering 385J (Topic 31). Same as: ECE 385J.31

Topic 2: Biomedical Instrumentation II: Real-Time Computer-Based Systems. Design, testing, patient safety, electrical noise, biomedical measurement transducers, therapeutics, instrumentation electronics, microcomputer interfaces, and embedded systems. Participate in an individual laboratory. Only one of the following may be counted: Biomedical Engineering 384J (Topic 2), Electrical and Computer Engineering 385J (Topic 17), Electrical Engineering 385J (Topic 17). Same as: ECE 385J.17

Topic 3: Biosignal Analysis. Theory and classification of biological signals such as EEG, EKG, and EMG. Data acquisition and analysis procedures for biological signals, including computer applications. Only one of the following may be counted: Biomedical Engineering 384J (Topic 3), Electrical and Computer Engineering 385J (Topic 15), Electrical Engineering 385J (Topic 15). Same as: ECE 385J.15

Topic 4: Bioelectric Phenomena. Examines the physiological bases of bioelectricity and the techniques required to record bioelectric phenomena both intracellularly and extracellularly; the representation of bioelectric activity by equivalent dipoles and the volume conductor fields produced. Only one of the following may be counted: Biomedical Engineering 384J (Topic 4), Electrical and Computer Engineering 385J (Topic 3), Electrical Engineering 385J (Topic 3). Same as: ECE 385J.3

Topic 5: Projects in Biomedical Engineering. An in-depth examination of selected topics, such as optical and thermal properties of laser interaction with tissue; measurement of perfusion in the microvascular system; diagnostic imaging; interaction of living systems with electromagnetic fields; robotic surgical tools; ophthalmic instrumentation; noninvasive cardiovascular measurements. Only one of the following may be counted: Biomedical Engineering 384J (Topic 5), Electrical and Computer Engineering 385J (Topic 32), Electrical Engineering 385J (Topic 32). Same as: ECE 385J.32 Additional prerequisite: Biomedical Engineering 384J (Topic 1) or Electrical and Computer Engineering 385J (Topic 31) (or Electrical Engineering 385J (Topic 31)).

Topic 6: Neurophysiology/Prosthesis Design. The structure and function of the human brain. Discussion of selected neurological diseases in conjunction with normal neurophysiology. Study of neuroprosthesis treatments and design philosophy, functional neural stimulation, and functional muscular stimulation. Only one of the following may be counted: Biomedical Engineering 385J (Topic 6), Electrical and Computer Engineering 385J (Topic 33), Electrical Engineering 385J (Topic 33). Same as: ECE 385J.33

Topic 7: Introduction to Neural Engineering. Survey of important concepts, applications, and challenges in neural engineering. Subjects include basic neurophysiology and electrophysiological signals, major neural interface modalities and various optical microscopy techniques, and design aspects of neural engineering devices. Emphasis on recent trends and frontiers in neural engineering. Only one of the following may be counted: Biomedical Engineering 381J (Topic: Electrophysiology: Methods and Frontiers), Biomedical Engineering 381J (Topic: Introduction to Neural Engineering), Biomedical Engineering 384J (Topic 7).

Topic 8: Rehabilitation Engineering. Explores use of robotic devices in physical therapy for neuromuscular injury. Clinicians lecture each week on a specific malady, followed by critical review of the literature of that malady from the perspective of rehabilitation engineering. Shadows therapists and develops a prototype of a device for therapy, assistance or diagnosis of patients, or conducts an experiment to test a hypothesis in the field using a device. Only one of the following may be counted: Biomedical Engineering 381J (Topic: Rehabilitation Engineering), 384J (Topic 8), Mechanical Engineering 385J (Topic 24), 397 (Topic: Rehabilitation Engineering). Three lecture hours a week for one semester. Same as: M E 385J.24

Topic 9: Bioelectronics and Biointerfaces. Examine critical concepts and strategies in materials development, electronics fabrication and genetic innovations that interface with biological systems. Explore neural interfacing technology, flexible electronics, wearable technology, bio-nanotechnology, and genetic engineering. Focus on the recently developed technology for recording and manipulating neural systems. Biomedical Engineering 384J (Topic: Bioelectronics/Biointerfaces) and 384J (Topic 9) may not both be counted.
  

BME 384J.1  Biomedical Instrumentation I  3 Hours  

3 Lecture Hours  0 Lab Hours  
Application of electrical engineering techniques to analysis and instrumentation in biological sciences: pressure, flow, temperature measurement; bioelectrical signals; pacemakers; ultrasonics; electrical safety; electrotherapeutics. Only one of the following may be counted: Biomedical Engineering 384J (Topic 1), Electrical and Computer Engineering 385J (Topic 31), Electrical Engineering 385J (Topic 31).
Same as: ECE 385J.31  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.2  Biomedical Instrumentation II: Real-Time Computer-Based Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Design, testing, patient safety, electrical noise, biomedical measurement transducers, therapeutics, instrumentation electronics, microcomputer interfaces, and embedded systems. Participate in an individual laboratory. Only one of the following may be counted: Biomedical Engineering 384J (Topic 2), Electrical and Computer Engineering 385J (Topic 17), Electrical Engineering 385J (Topic 17).
Same as: ECE 385J.17  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.3  Biosignal Analysis  3 Hours  

3 Lecture Hours  0 Lab Hours  
Theory and classification of biological signals such as EEG, EKG, and EMG. Data acquisition and analysis procedures for biological signals, including computer applications. Only one of the following may be counted: Biomedical Engineering 384J (Topic 3), Electrical and Computer Engineering 385J (Topic 15), Electrical Engineering 385J (Topic 15).
Same as: ECE 385J.15  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.4  Bioelectric Phenomena  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examines the physiological bases of bioelectricity and the techniques required to record bioelectric phenomena both intracellularly and extracellularly; the representation of bioelectric activity by equivalent dipoles and the volume conductor fields produced. Only one of the following may be counted: Biomedical Engineering 384J (Topic 4), Electrical and Computer Engineering 385J (Topic 3), Electrical Engineering 385J (Topic 3).
Same as: ECE 385J.3  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.5  Projects in Biomedical Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
An in-depth examination of selected topics, such as optical and thermal properties of laser interaction with tissue; measurement of perfusion in the microvascular system; diagnostic imaging; interaction of living systems with electromagnetic fields; robotic surgical tools; ophthalmic instrumentation; noninvasive cardiovascular measurements. Only one of the following may be counted: Biomedical Engineering 384J (Topic 5), Electrical and Computer Engineering 385J (Topic 32), Electrical Engineering 385J (Topic 32).
Same as: ECE 385J.32  
Pre/Corequisites: Biomedical Engineering 384J (Topic 1) or Electrical and Computer Engineering 385J (Topic 31) (or Electrical Engineering 385J (Topic 31)).  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.6  Neurophysiology/Prosthesis Design  3 Hours  

3 Lecture Hours  0 Lab Hours  
The structure and function of the human brain. Discussion of selected neurological diseases in conjunction with normal neurophysiology. Study of neuroprosthesis treatments and design philosophy, functional neural stimulation, and functional muscular stimulation. Only one of the following may be counted: Biomedical Engineering 385J (Topic 6), Electrical and Computer Engineering 385J (Topic 33), Electrical Engineering 385J (Topic 33).
Same as: ECE 385J.33  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.7  Introduction to Neural Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Survey of important concepts, applications, and challenges in neural engineering. Subjects include basic neurophysiology and electrophysiological signals, major neural interface modalities and various optical microscopy techniques, and design aspects of neural engineering devices. Emphasis on recent trends and frontiers in neural engineering. Only one of the following may be counted: Biomedical Engineering 381J (Topic: Electrophysiology: Methods and Frontiers), Biomedical Engineering 381J (Topic: Introduction to Neural Engineering), Biomedical Engineering 384J (Topic 7).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.8  Rehabilitation Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explores use of robotic devices in physical therapy for neuromuscular injury. Clinicians lecture each week on a specific malady, followed by critical review of the literature of that malady from the perspective of rehabilitation engineering. Shadows therapists and develops a prototype of a device for therapy, assistance or diagnosis of patients, or conducts an experiment to test a hypothesis in the field using a device. Only one of the following may be counted: Biomedical Engineering 381J (Topic: Rehabilitation Engineering), 384J (Topic 8), Mechanical Engineering 385J (Topic 24), 397 (Topic: Rehabilitation Engineering). Three lecture hours a week for one semester.
Same as: M E 385J.24  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384J.9  Bioelectronics and Biointerfaces  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine critical concepts and strategies in materials development, electronics fabrication and genetic innovations that interface with biological systems. Explore neural interfacing technology, flexible electronics, wearable technology, bio-nanotechnology, and genetic engineering. Focus on the recently developed technology for recording and manipulating neural systems. Biomedical Engineering 384J (Topic: Bioelectronics/Biointerfaces) and 384J (Topic 9) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384T  Topics in Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Three lecture hours a week for one semester, or as required by the topic.
Pre/Corequisites: Graduate standing and consent of instructor; additional prerequisites vary with the topic.  
Restrictions: Restricted to students in the Cockrell School of Engineering.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Doctoral  
Topic 1: Bioheat Transfer. Explore the application of the principles of heat transfer to the solution of a series of advanced, open-ended problems in medicine and biology. Identify and pursue solution strategies for a range of cutting-edge problems in bioheat transfer. Biomedical Engineering 384T (Topic 1) and 385J (Topic 12) may not both be counted. Additional prerequisite: Prior course in heat transfer or transport phenomena.

Topic 2: Cellular, Tissue, and Scaffold Biomechanics. Explore an analysis of biosolid mechanics via the mechanical behavior of scaffolds and living tissues and cells. Examine biomechanical application areas, including cell mechanics, engineered materials, hard and soft tissues, and organs. Only one of the following may be counted: Biomedical Engineering 384T (Topic 2), 385J (Topic: Tissue/Scaffold Biomechanics), 385J (Topic 7).

Topic 3: Soft Tissue Biomechanics. Explore the fundamentals and critical applications of soft tissue mechanics. Examine continuum mechanics (kinematics, stress, balance of linear momentum, hyperelasticity), experimental and nonlinear finite element analyses of soft tissue mechanics, and relevant imaging modalities and related facilities available on campus. Only one of the following may be counted: Biomedical Engineering 384T (Topic 3), 385J (Topic: Soft Tissue Biomechanics), Engineering Mechanics 397 (Topic: Soft Tissue Biomechanics), Mechanical Engineering 385J (Topic: Soft Tissue Biomechanics).

Topic 4: Thin Film Mechanics. Explore a comprehensive introduction to, and important applications of, thin film structures and devices. Discuss stress, fracture, delamination, instability, and other mechanics-related subjects involving thin films. Examine technological applications including integrated circuits, micro- and nano-electromechanical systems, flexible and stretchable electronics, bioelectronics, and surface coatings. Only one of the following may be counted: Biomedical Engineering 384T (Topic 4), 385J (Topic: Thin Film Mechanics), Engineering Mechanics 397 (Topic: Thin Film Mechanics).

Topic 5: Tissue Microenvironments. Explore varying native and bio-fabricated tissue microenvironments and hands-on opportunities for fabrication and bioprinting of tissues on a chip. Examine characterization of mechanical, thermal, transport, and cellular tissue response to microenvironments; imaging and computational approaches that enable prediction of cell and tissue behavior within physiological and pathological native or bio-fabricated tissues; and clinical perspectives which drive design of physiologically representative tissues on a chip and their use for diagnostic screening and therapeutic planning. Only one of the following may be counted: Biomedical Engineering 384T (Topic 5), 385J (Topic: Tiss Microenv: Fab/Tran/Mech), Mechanical Engineering 397 (Topic: Tiss Microenv: Fab/Tran/Mech), 397M (Topic: Tiss Microenv: Fab/Tran/Mech).
  

BME 384T.1  Bioheat Transfer  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore the application of the principles of heat transfer to the solution of a series of advanced, open-ended problems in medicine and biology. Identify and pursue solution strategies for a range of cutting-edge problems in bioheat transfer. Biomedical Engineering 384T (Topic 1) and 385J (Topic 12) may not both be counted.
Pre/Corequisites: Prior course in heat transfer or transport phenomena.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384T.2  Cellular, Tissue, and Scaffold Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore an analysis of biosolid mechanics via the mechanical behavior of scaffolds and living tissues and cells. Examine biomechanical application areas, including cell mechanics, engineered materials, hard and soft tissues, and organs. Only one of the following may be counted: Biomedical Engineering 384T (Topic 2), 385J (Topic: Tissue/Scaffold Biomechanics), 385J (Topic 7).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384T.3  Soft Tissue Biomechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore the fundamentals and critical applications of soft tissue mechanics. Examine continuum mechanics (kinematics, stress, balance of linear momentum, hyperelasticity), experimental and nonlinear finite element analyses of soft tissue mechanics, and relevant imaging modalities and related facilities available on campus. Only one of the following may be counted: Biomedical Engineering 384T (Topic 3), 385J (Topic: Soft Tissue Biomechanics), Engineering Mechanics 397 (Topic: Soft Tissue Biomechanics), Mechanical Engineering 385J (Topic: Soft Tissue Biomechanics).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384T.4  Thin Film Mechanics  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore a comprehensive introduction to, and important applications of, thin film structures and devices. Discuss stress, fracture, delamination, instability, and other mechanics-related subjects involving thin films. Examine technological applications including integrated circuits, micro- and nano-electromechanical systems, flexible and stretchable electronics, bioelectronics, and surface coatings. Only one of the following may be counted: Biomedical Engineering 384T (Topic 4), 385J (Topic: Thin Film Mechanics), Engineering Mechanics 397 (Topic: Thin Film Mechanics).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 384T.5  Tissue Microenvironments  3 Hours  

3 Lecture Hours  0 Lab Hours  
Explore varying native and bio-fabricated tissue microenvironments and hands-on opportunities for fabrication and bioprinting of tissues on a chip. Examine characterization of mechanical, thermal, transport, and cellular tissue response to microenvironments; imaging and computational approaches that enable prediction of cell and tissue behavior within physiological and pathological native or bio-fabricated tissues; and clinical perspectives which drive design of physiologically representative tissues on a chip and their use for diagnostic screening and therapeutic planning. Only one of the following may be counted: Biomedical Engineering 384T (Topic 5), 385J (Topic: Tiss Microenv: Fab/Tran/Mech), Mechanical Engineering 397 (Topic: Tiss Microenv: Fab/Tran/Mech), 397M (Topic: Tiss Microenv: Fab/Tran/Mech).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 385J  Topics in Biomedical Engineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Biomedical Engineering 385J and 387J may not both be counted unless the topics vary. Three lecture hours a week for one semester, or as required by the topic.
Pre/Corequisites: Graduate standing in engineering and consent of instructor.  
Grading: Student Option  
Repeatable for credit: May be repeated for credit when the topics vary.  
Academic Level: Doctoral  
Topic 1: Cell and Tissue Anatomy and Physiology for Engineers. An overview of cellular biology, including functional cellular anatomy, DNA replication and the cell cycle, protein synthesis, membrane structure and function, energy metabolism, cellular homeostasis, and cell repair and death; and functional anatomy and physiology of the basic tissues. Normally offered in the fall semester only.

Topic 2: Organ System Anatomy, Physiology, and Pathology for Engineers. The functional anatomy and physiology of the major human organ systems; representative pathologic disorders associated with these organs. An overview of general pathologic processes, with emphasis on the influences of normal and abnormal organ anatomy, physiology, and disease on the definition and solution of biomedical engineering problems. Two lecture hours and one three-hour laboratory a week for one semester. Normally offered in the spring semester only. Additional prerequisite: Biomedical Engineering 385J (Topic 1) or the equivalent.

Topic 3: Bioelectric Phenomena. Examines the physiological bases of bioelectricity and the techniques required to record bioelectric phenomena both intracellularly and extracellularly; the representation of bioelectric activity by equivalent dipoles and the volume conductor fields produced. Normally offered in the fall semester only.

Topic 4: Electrophysiology of the Nervous System. Introduction to anatomy, physiology, and function of the human nervous system. Normally offered in the fall semester only.

Topic 5: Cardiovascular Dynamics. Anatomy, physiology, pathophysiology, and dynamics of the cardiovascular system, with emphasis on the design and application of electrical and mechanical devices for cardiac intervention. Normally offered in the fall semester only.

Topic 6: Analysis of Biological Systems. Biomedical Engineering 383J (Topic: Analysis of Biological Systems I) and 385J (Topic 6) may not both be counted.

Topic 7: Tissue and Cell Biomechanics Applications. Analysis of biosolid mechanics via the mechanical behavior of scaffolds and living tissues and cells. Emphasis on biomechanical application areas, including cell mechanics, engineered materials, hard and soft tissues, and organs. Biomedical Engineering 385J (Topic: TISSUE/SCAFFOLD BIOMECHANICS) and 385J (Topic 7) may not both be counted.

Topic 8: Dynamics of Blood Flow. The circulatory system, heart function and blood physiology, steady and oscillatory fluid flow and wave propagation in the circulatory system, rheology of blood.

Topic 9: Laser-Tissue Interaction: Thermal. The thermal response of random media in interaction with laser irradiation. Calculation of the rate of heat production caused by direct absorption of the laser light, thermal damage, and ablation. Normally offered in the spring semester only.

Topic 11: Biomedical Engineering Hospital Interfaces. Students gain firsthand knowledge of the instrumentation, procedures, and organization of a modern hospital. Class sessions are held in the different clinical services and laboratories of the hospital. Normally offered in the spring semester only.

Topic 12: Biomedical Heat Transfer. Application of the principles of heat transfer to the solution of a series of advanced, open-ended problems in medicine and biology. Inquiry learning format in which students take personal responsibility for identifying and pursuing solution strategies for a range of cutting edge problems in bioheat transfer. Additional prerequisite: Biomedical Engineering 353, Chemical Engineering 319 (or 353), or another course in transport phenomena.

Topic 13: Molecular Recognition in Biology and Biotechnology.

Topic 14: Biomaterials and Biorheology. Properties of biomaterials, their structure and mechanical properties in deformation and flow; polymers and natural biological materials.

Topic 15: Biosignal Analysis. Theory and classification of biological signals such as EEG, EKG, and EMG. Data acquisition and analysis procedures for biological signals, including computer applications. Normally offered in the spring semester only.

Topic 16: Laser-Tissue Interaction: Optical. The optical behavior of random media such as tissue in interaction with laser irradiation. Approximate transport equation methods to predict the absorption and scattering parameters of laser light inside tissue. Port-wine stain treatment; cancer treatment by photochemotherapy; and cardiovascular applications. Normally offered in the fall semester only.

Topic 17: Biomedical Instrumentation II: Real-Time Computer-Based Systems. Design, testing, patient safety, electrical noise, biomedical measurement transducers, therapeutics, instrumentation electronics, and microcomputer interfaces. Several case studies are presented. Additional topics are covered in Biomedical Engineering 685J (Topic 17). Four structured laboratories and an individual project laboratory. Biomedical Engineering 385J (Topic 17) and 685J (Topic 17) normally meet with Electrical Engineering 385J (Topic 17) and 685J (Topic 17). Normally offered in the fall semester only.

Topic 18: Biomedical Image Processing. Physical principles and signal processing techniques used in thermographic, ultrasonic, and radiographic imaging, including image reconstruction from projections such as CT scanning, MRI, and millimeter wave determination of temperature profiles. Normally offered in the spring semester only. Additional prerequisite: Electrical Engineering 371R.

Topic 19: Neuropathophysiology/Prostheses. Detection and treatment of disorders of the nervous system: neuromuscular and cerebrovascular disease, brain tumors, psychiatric and developmental disorders. Prostheses for hearing, visual, and limb impairments. Students design and test a neuroprosthesis. Normally offered in the spring semester only. Additional prerequisite: Biomedical Engineering 385J (Topic 1); or Biomedical Engineering 385J (Topic 3) and Zoology 383K; or Zoology 383K and 383L.

Topic 20: Network Thermodynamics in Biophysics. Modeling and simulation methods for nonlinear biological processes, including coupling across multienergy domains; practical implementation by bond graph techniques. Normally offered in the spring semester only. Additional prerequisite: Mechanical Engineering 344 or consent of instructor.

Topic 22: Musculoskeletal Biomechanics. Synthesis of properties of the musculotendon and skeletal systems to construct detailed computer models that quantify human performance and muscular coordination. Additional prerequisite: Additional prerequisite for kinesiology students: Mathematics 341 (or 311) and Kinesiology 395 (Topic 36: Biomechanics of Human Movement).

Topic 23: Optical Spectroscopy. Measurement and interpretation of spectra: steady-state and time-resolved absorption, fluorescence, phosphorescence, and Raman spectroscopy in the ultraviolet, visible, and infrared portions of the spectrum. Normally offered in the fall semester only.

Topic 25: Advanced Biochemical Engineering. Large-scale production of proteins, protein engineering, mammalian tissue culture technology, and protein separations.

Topic 26: Therapeutic Heating. Engineering aspects of electromagnetic fields that have therapeutic applications: diathermy (short wave, microwave, and ultrasound), electrosurgery (thermal damage processes), stimulation of excitable tissue, and electrical safety. Normally offered in the spring semester only.

Topic 27: The Biotechnology Revolution and Engineering Ethics. The history and status of genetic engineering; potential applications in medicine, agriculture, and industry; ethical and social issues surrounding the engineering of biological organisms; ethics in engineering practice in physical and biological realms. Normally offered in the spring semester only.

Topic 28: Noninvasive Optical Tomography. Basic principles of optical tomographic imaging of biological materials for diagnostic or therapeutic applications. Optical-based tomographic imaging techniques including photothermal, photoacoustic, and coherent methodologies.

Topic 29: Transport Processes in Biological Systems. Introduction to engineering analysis of transport phenomena in living systems, including fluid flow, heat transfer, pharmacokinetics, and membrane fluxes with clinical applications.

Topic 30: Introduction to Biomechanics. Modeling and simulation of human movement; neuromuscular control; computer applications; introduction to experimental techniques. Three lecture hours and one laboratory hour a week for one semester.

Topic 31: Biomedical Instrumentation I. Application of electrical engineering techniques to analysis and instrumentation in biological sciences: pressure, flow, temperature measurement; bioelectrical signals; pacemakers; ultrasonics; electrical safety; electrotherapeutics.

Topic 32: Projects in Biomedical Engineering. An in-depth examination of selected topics, such as optical and thermal properties of laser interaction with tissue; measurement of perfusion in the microvascular system; diagnostic imaging; interaction of living systems with electromagnetic fields; robotic surgical tools; ophthalmic instrumentation; noninvasive cardiovascular measurements. Three lecture hours and six laboratory hours a week for one semester. Additional prerequisite: Biomedical Engineering 385J (Topic 31).

Topic 33: Neurophysiology/Prosthesis Design. The structure and function of the human brain. Discussion of selected neurological diseases in conjunction with normal neurophysiology. Study of neuroprosthesis treatments and design philosophy, functional neural stimulation, and functional muscular stimulation. Normally offered in the fall semester only.

Topic 34: Biopolymers and Drug/Gene Delivery. Introduction to different classes of biopolymers. Biodegradability and biocompatibility. Interaction of cells and tissues with polymers and polymeric implants; immunology of biomaterials. Applications of polymers in medicine and biology. Gene therapy and generic immunization. The use of biopolymers and drug/gene delivery in organ regeneration and tissue engineering. Offered in the fall semester only.

Topic 35: Ten Unsolved Questions in Neuroscience.

Topic 36: Engineering Applications of Immunology and Disease Pathology.

Topic 37: Functional Imaging: Principles, Approaches, and Applications.

Topic 38: The Synaptic Basis for Learning and Memory. Abstract models and biophysical models of synaptic plasticity. Includes guest lectures from experimentalists working in this field.

Topic 39: Medical Decision Making. Selected subjects from cognitive psychology and human-machine interaction for engineering students to design more effective systems for supporting medical decision making. Biomedical Engineering 385J (Topic: Medical Decision Making) and 385J (Topic 39) may not both be counted.

Topic 40: Cancer Bioengineering. Analysis of the biology and pathology of cancer, including the fundamental nature of cancer, cellular oncogenes, growth factor signaling, tumor suppressor genes, apoptosis, multi-step tumorigenesis, angiogenesis, metastasis, and tumor immunology and immunotherapy. Also explores ways in which the tools of engineering are transforming the future of cancer research. Biomedical Engineering 385J (Topic: Cancer Bioengineering) and 385J (Topic 40) may not both be counted.

Topic 41: Medical Device Design and Manufacturing. Apply engineering principles in the conception, design and prototyping of medical devices. Develop team projects with emphasis on clinical and market needs analysis, creative and useful concept generation, engineering requirements and specifications, and written and oral reporting of intermediate and final prototype outcomes. Biomedical Engineering 385J (Topic: Medical Device Design and Manu) and 385J (Topic 41) may not both be counted. Three lecture hours a week for one semester.

Topic 42: Inquiry Based Instructional Design. Examine principles of inquiry-based learning methods and their applications to an engineering pedagogical context. Use multiple, open-ended engineering problems as case studies and develop an independent course integrating inquiry-based learning content. Only one of the following may be counted: Biomedical Engineering 385J (Topic: Dsgn IBL: Bioheat Transfer), 385J (Topic: Inquiry Based Instruc Dsgn), 385J (Topic 42).
  

BME 385J.39  Medical Decision Making  3 Hours  

3 Lecture Hours  0 Lab Hours  
Selected subjects from cognitive psychology and human-machine interaction for engineering students to design more effective systems for supporting medical decision making. Biomedical Engineering 385J (Topic: Medical Decision Making) and 385J (Topic 39) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 385J.40  Cancer Bioengineering  3 Hours  

3 Lecture Hours  0 Lab Hours  
Analysis of the biology and pathology of cancer, including the fundamental nature of cancer, cellular oncogenes, growth factor signaling, tumor suppressor genes, apoptosis, multi-step tumorigenesis, angiogenesis, metastasis, and tumor immunology and immunotherapy. Also explores ways in which the tools of engineering are transforming the future of cancer research. Biomedical Engineering 385J (Topic: Cancer Bioengineering) and 385J (Topic 40) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 385J.41  Medical Device Design and Manufacturing  3 Hours  

3 Lecture Hours  0 Lab Hours  
Apply engineering principles in the conception, design and prototyping of medical devices. Develop team projects with emphasis on clinical and market needs analysis, creative and useful concept generation, engineering requirements and specifications, and written and oral reporting of intermediate and final prototype outcomes. Biomedical Engineering 385J (Topic: Medical Device Design and Manu) and 385J (Topic 41) may not both be counted. Three lecture hours a week for one semester.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 385J.42  Inquiry Based Instructional Design  3 Hours  

3 Lecture Hours  0 Lab Hours  
Examine principles of inquiry-based learning methods and their applications to an engineering pedagogical context. Use multiple, open-ended engineering problems as case studies and develop an independent course integrating inquiry-based learning content. Only one of the following may be counted: Biomedical Engineering 385J (Topic: Dsgn IBL: Bioheat Transfer), 385J (Topic: Inquiry Based Instruc Dsgn), 385J (Topic 42).
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 385J.6  Analysis of Biological Systems  3 Hours  

3 Lecture Hours  0 Lab Hours  
Biomedical Engineering 383J (Topic: Analysis of Biological Systems I) and 385J (Topic 6) may not both be counted.
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 685M  Mechanisms of Disease  6 Hours  

6 Lecture Hours  0 Lab Hours  
Overview of the disease-specific concepts required to participate in patient care by integrating clinical medicine, microbiology, pathology, and pharmacology into organ system modules, and the pathophysiology of diseases, the differential diagnosis of cardinal symptoms, and treatment modalities. Includes other concepts such as radiology and diagnostics. Six lecture hours a week for one semester.
Restrictions: Restricted to students in the Master of Science in Engineering and Doctor of Medicine dual-degree program.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Master's  

BME 386J  Biomedical Engineering Microscopy Foundations Laboratory  3 Hours  

1.5 Lecture Hours  3 Lab Hours  
Explore finite and infinite imagery; conjugate planes, back focal plan manipulation, Abbe theory image formation, point spread functions, camera principles, fluorescence, and advanced fluorescence techniques. Build an optical microscope. Only one of the following may be counted: Biomedical Engineering 381J (Topic: Biomd Eng Mcrscpy Fndtn Lab), 381J (Topic: Microscopy Fundamentals), 386J. One-and-one-half lecture hours and three laboratory hours a week for one semester.
Pre/Corequisites: Graduate standing in engineering and consent of instructor; prior course in linear systems and signals.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 396  Research Internship  3 Hours  

20 Lecture Hours  0 Lab Hours  
Students participate in research in an industry, clinic, or academic laboratory setting selected with the approval of the faculty adviser. May be counted only once toward either the master's or the doctoral degree. At least twenty hours of fieldwork a week for one semester.
Pre/Corequisites: Graduate standing.  
Grading: Credit No Credit  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 197, 297, 397, 597, 697  Research Problems  1,2,3,5,6 Hours  

0 Lecture Hours  3,6,9,15,18 Lab Hours  
Problems selected by the student with approval of the faculty adviser. For each semester hour of credit earned, three laboratory hours a week for one semester.
Pre/Corequisites: Graduate standing in biomedical engineering.  
Grading: Credit No Credit  
Repeatable for credit: No  

BME 197D  Deep Reading in Science and Engineering  1 Hour  

1 Lecture Hours  0 Lab Hours  
Analyze primary research articles with the goal of improving understanding of experimental design/methods, writing scientific articles and critiquing current research. The equivalent of one lecture hour a week for one semester.
Pre/Corequisites: Graduate standing and consent of instructor.  
Grading: Credit No Credit  
Repeatable for credit: Yes (Unlimited)  
Academic Level: Doctoral  

BME 197E  Professional Responsibilities in Imaging  1 Hour  

1 Lecture Hours  0 Lab Hours  
One lecture hour a week for one semester.
Pre/Corequisites: Graduate standing.  
Grading: Credit No Credit  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 197M  Mentoring Undergraduates in Research  1 Hour  

1 Lecture Hours  0 Lab Hours  
Designed to support and develop students' skills in mentoring undergraduates engaged in science, technology, engineering and mathematics (STEM) research. Biomedical Engineering 180J (Topic: Research Mentoring) and 197M may not both be counted. The equivalent of one lecture hour a week for one semester.
Pre/Corequisites: Graduate standing.  
Grading: Credit No Credit  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 197N  Integrated Biomedical Engineering Seminar  1 Hour  

1 Lecture Hours  0 Lab Hours  
Designed to support students' professional development as well as their broad understanding of the biomedical engineering research enterprise. One lecture hour a week for one semester.
Pre/Corequisites: Graduate standing.  
Grading: Student Option  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 197P, 297P, 397P  Graduate Professional Development Seminar  1-3 Hours  

1,2,3 Lecture Hours  0 Lab Hours  
Explores professional development goals of biomedical engineers. Subjects include an individual development plan, careers in academia, entrepreneurship, careers in industry, and more. For each semester hour of credit earned, one lecture hour a week for one semester.
Grading: Credit No Credit  
Repeatable for credit: No  
Academic Level: Doctoral  

BME 197S  Graduate Seminar in Biomedical Engineering  1 Hour  

1 Lecture Hours  0 Lab Hours  
The equivalent of one lecture hour a week for one semester.
Pre/Corequisites: Graduate standing.  
Grading: Credit No Credit  
Repeatable for credit: Yes (Unlimited)  

BME 698  Thesis  6 Hours  

3 Lecture Hours  0 Lab Hours  
The equivalent of three lecture hours a week for two semesters.
Pre/Corequisites: For 698A, graduate standing in biomedical engineering and consent of the graduate adviser; for 698B, Biomedical Engineering 698A.  
Grading: Credit No Credit  
Repeatable for credit: No  
Academic Level: Master's  

BME 398R  Master's Report  3 Hours  

0 Lecture Hours  0 Lab Hours  
Preparation of a report to fulfill the requirement for the master's degree under the report option. The equivalent of three lecture hours a week for one semester.
Pre/Corequisites: Graduate standing in biomedical engineering and consent of the graduate adviser.  
Grading: Credit No Credit  
Repeatable for credit: No  
Academic Level: Master's  

BME 399W, 699W, 999W  Dissertation  3,6,9 Hours  

0 Lecture Hours  0 Lab Hours  
Pre/Corequisites: Admission to candidacy for the doctoral degree.  
Grading: Credit No Credit  
Repeatable for credit: Yes (Unlimited)  
Academic Level: Doctoral